A two-neuron system for adaptive goal-directed decision-making in Lymnaea.
A two-neuron system for adaptive goal-directed decision-making in Lymnaea.
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DOI：
10.1038/ncomms11793
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发表时间：
2016-06-03
影响因子：
16.6
通讯作者：
Kemenes G
中科院分区：
文献类型：
--
作者：
Crossley M;Staras K;Kemenes G
在目标导向的决策过程中，动物必须整合来自外部环境和内部状态的信息，以最大限度地实现资源定位，同时最大限度地减少能量消耗。神经系统如何解决这个复杂的问题仍然知之甚少。在这里，使用相结合的行为和神经生理学的方法，我们证明了软体动物的食蟹猴执行一个复杂的形式的决策过程中的搜索行为，使用的核心系统组成的只有两种神经元类型。第一个报告的存在下的食物和第二个编码的动机状态作为一个增益控制器的适应行为在没有食物。使用体外模拟的决策过程中，我们表明，该系统采用了能源管理策略，根据决策的结果在低和高使用模式之间切换。我们的研究揭示了一种简约的机制，通过调节紧张性抑制和相位兴奋的水平来驱动复杂的决策过程。 整合来自外部环境和生物体内部状态的信息是与喂养相关的决策的重要方面。在这里，作者确定了一个两个神经元电路内的软体动物的神经，适应喂养行为根据食物的可用性和动机状态。
During goal-directed decision-making, animals must integrate information from the external environment and their internal state to maximize resource localization while minimizing energy expenditure. How this complex problem is solved by the nervous system remains poorly understood. Here, using a combined behavioural and neurophysiological approach, we demonstrate that the mollusc Lymnaea performs a sophisticated form of decision-making during food-searching behaviour, using a core system consisting of just two neuron types. The first reports the presence of food and the second encodes motivational state acting as a gain controller for adaptive behaviour in the absence of food. Using an in vitro analogue of the decision-making process, we show that the system employs an energy management strategy, switching between a low- and high-use mode depending on the outcome of the decision. Our study reveals a parsimonious mechanism that drives a complex decision-making process via regulation of levels of tonic inhibition and phasic excitation. Integrating information from both the external environment and an organism's internal state is an important aspect of feeding-related decision making. Here, the authors identify a two neuron circuit within the mollusc Lymnaea that adapts feeding behaviour according to food availability and motivational state.