Hyperbaric oxygen and radiobiology of a C3H mouse mammary carcinoma.
Hyperbaric oxygen and radiobiology of a C3H mouse mammary carcinoma.
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C3H 小鼠乳腺癌的高压氧和放射生物学。
DOI：
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发表时间：
1967
期刊：
影响因子：
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通讯作者：
M. Maeda
中科院分区：
文献类型：
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作者：
H. Suit;M. Maeda
对第一代至第四代C3H/J小鼠乳腺癌移植瘤进行了一系列的辐射剂量-肿瘤控制反应分析，并在四种不同条件下进行了放射治疗：低氧，治疗前夹在荷瘤部位根部1分钟；空气，动物在一个气压下呼吸空气；氧气30或44磅/平方英寸，动物在局部肿瘤照射前和照射期间以30或44磅/平方英寸的纯氧呼吸15分钟。单次照射250mm3肿瘤时，高压氧仅对降低肿瘤控制量(TCD50)有一定作用，TCD50低氧/O2 30psi和TCD50低氧/O2 44psi分别为1.2和1.3psi。然而，对于0.6mm3肿瘤和更小的“微集落”的类似治疗，TCD50缺氧/O2 44psi的比率分别为2.5和3.2。这些结果针对简单的肿瘤模型进行了讨论，以估计正常情况下肿瘤中存在的低氧细胞的比例，以及在加压时呼吸的氧气对这一比例的影响。高压氧联合分次照射(v=10)比单剂量治疗有效得多。因此，TCD50缺氧/O2 30psi为2.2(v=10)而不是1.2(v=1)。缺氧TCD50=10/v=1的比值为2.15。对这些结果进行了回顾，并对正常条件下分次照射(v=10)期间肿瘤细胞在治疗之间的增殖程度、低氧细胞对亚致死性辐射损伤的修复以及细胞从低氧室到有氧室的移动进行了回顾和推论。
A series of radiation dose-tumor control response assays was performed on the first-to-fourth generation isotransplants of a C3H/J mouse mammary carcinoma for radiation administered under four different conditions: hypoxia, a clamp across the root of the tumor-bearing part for 1 minute before treatment; air, animal respiring air at one atmosphere of pressure; O2 30 or 44 psi, animal respiring pure oxygen at 30 or 44 psi for 15 minutes before and during local tumor irradiation. When radiation was administered as a single dose (v = 1) to 250 mm3 tumors, high pressure oxygen was only modestly effective in reducing the tumor control dose (TCD50); TCD50 hypoxia/O2 30 psi and TCD50 hypoxia/O2 44 psi were only 1.2 and 1.3, respectively. However, for similar treatment of 0.6 mm3 tumors and of even smaller "microcolonies," the ratios TCD50 hypoxia/O2 44 psi were 2.5 and 3.2, respectively. These results are discussed with respect to simple tumor models so as to estimate the proportion of hypoxic cells present in tumors under normal conditions and the influence of oxygen breathed at increased pressure on that proportion. High pressure oxygen was found much more effective when combined with fractionated irradiation (v = 10) than with single-dose therapy. Thus TCD50 hypoxia/O2 30 psi was 2.2 (v = 10) instead of 1.2 (v = 1). Finally, the ratio TCD50 hypoxia = 10/v = 1 was 2.15. These results are reviewed and inferences drawn as to the extent of tumor cell proliferation between treatments, repair of sublethal radiation injury by hypoxic cells, and the movement of cells from the hypoxic compartment to the aerobic compartment during fractionated irradiation (v = 10) under normal conditions.