Total synthesis of (+)-tanikolide, using regioselective elimination of a vicinal dibromoalkane
Total synthesis of (+)-tanikolide, using regioselective elimination of a vicinal dibromoalkane
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DOI：
10.1246/bcsj.78.1549
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发表时间：
2005-08-15
影响因子：
4
通讯作者：
Nishiyama, S
中科院分区：
文献类型：
--
作者：
Ohgiya, T;Nakamura, K;Nishiyama, S
以相应的1-酰氧基-2，3-二溴代烷为原料，通过区域选择性和温和的HBr消除反应，结合钯介导的C-C偶联反应和夏普莱斯不对称环氧化反应，成功地合成了海洋来源的具有生物活性的三角洲-内酯(+)-tanikolide。
Total synthesis of (+)-tanikolide, a bioactive delta-lactone of marine origin, was successfully accomplished by utilizing a bromoalkene derivative conveniently synthesized from the corresponding 1-acyloxy-2,3-dibromoalkane by the regioselective and mild HBr-elimination reaction, along with the Pd-mediated C-C coupling reaction and the Sharpless asymmetric epoxidation as key steps.