I too, am America: a review of research on systemic lupus erythematosus in African-Americans.
I too, am America: a review of research on systemic lupus erythematosus in African-Americans.
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DOI：
10.1136/lupus-2015-000144
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发表时间：
2016
影响因子：
3.9
通讯作者：
Oates JC
中科院分区：
文献类型：
--
作者：
Williams EM;Bruner L;Adkins A;Vrana C;Logan A;Kamen D;Oates JC
系统性红斑狼疮（SLE）是一种多器官自身免疫性疾病，可导致显着的发病率和死亡率。大量证据表明，非洲裔美国人比其他种族更严重地经历了这种疾病。从PubMed、Scopus和EBSCOHost平台（包括MEDLINE、CINAHL等）的系统性检索中获得2000年至2015年8月的相关文献，以评价关注非裔美国人SLE的研究。1502篇文章中有36篇根据其证据等级进行了分类。系统性文献综述报告了非裔美国SLE患者的广泛不良结局以及在其他单种族和多种族研究中观察到的风险因素。仅限于非裔美国人SLE患者的研究确定了更精确确定风险的新方法，并观察到以前在非裔美国人SLE患者中未报道的新发现。本综述中包括的环境和遗传研究都强调了独特的非洲裔美国人群体，试图隔离归因于非洲血统的风险，并观察到该队列中遗传对整体疾病的影响增加。审查还揭示了生活质量，种族定制的干预措施和自我管理等领域的新兴研究。这篇综述再次强调了进一步研究的重要性，以更好地阐明非裔美国人SLE的自然史，并优化那些被确定为高危人群的治疗策略。
Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder that can cause significant morbidity and mortality. A large body of evidence has shown that African-Americans experience the disease more severely than other racial-ethnic groups. Relevant literature for the years 2000 to August 2015 were obtained from systematic searches of PubMed, Scopus, and the EBSCOHost platform that includes MEDLINE, CINAHL, etc. to evaluate research focused on SLE in African-Americans. Thirty-six of the 1502 articles were classified according to their level of evidence. The systematic review of the literature reported a wide range of adverse outcomes in African-American SLE patients and risk factors observed in other mono and multi-ethnic investigations. Studies limited to African-Americans with SLE identified novel methods for more precise ascertainment of risk and observed novel findings that hadn't been previously reported in African-Americans with SLE. Both environmental and genetic studies included in this review have highlighted unique African-American populations in an attempt to isolate risk attributable to African ancestry and observed increased genetic influence on overall disease in this cohort. The review also revealed emerging research in areas of quality of life, race-tailored interventions, and self-management. This review reemphasizes the importance of additional studies to better elucidate the natural history of SLE in African-Americans and optimize therapeutic strategies for those who are identified as being at high risk.