CIDE Proteins and Lipid Metabolism
CIDE Proteins and Lipid Metabolism
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CIDE 蛋白质和脂质代谢
DOI：
10.1161/atvbaha.111.241489
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发表时间：
2012-05-01
影响因子：
8.7
通讯作者：
Li, Peng
中科院分区：
文献类型：
--
作者：
Xu, Li;Zhou, Linkang;Li, Peng
脂质稳态是通过脂质代谢在包括脂肪组织和肝脏在内的各种组织中的协调来维持的。脂质稳态的破坏常常导致代谢紊乱，如肥胖、糖尿病、肝脂肪变性和心血管疾病。细胞死亡诱导DNA片段因子45样效应家族蛋白，包括Cidea、Cideb和Fsp27 (Cidec)，正在成为各种脂质代谢途径的重要调节因子，并在代谢疾病的发展中发挥关键作用。本文综述了与脂质代谢控制相关的细胞死亡诱导DNA片段因子45样效应蛋白的最新发现，重点介绍了这些蛋白在脂肪细胞脂滴生长和肝细胞极低密度脂蛋白脂化和成熟调控中的作用。（中华动脉血管杂志，2012;32:1094-1098）
Lipid homeostasis is maintained through the coordination of lipid metabolism in various tissues, including adipose tissue and the liver. The disruption of lipid homeostasis often results in the development of metabolic disorders such as obesity, diabetes mellitus, liver steatosis, and cardiovascular diseases. Cell death-inducing DNA fragmentation factor 45-like effector family proteins, including Cidea, Cideb, and Fsp27 (Cidec), are emerging as important regulators of various lipid metabolic pathways and play pivotal roles in the development of metabolic disorders. This review summarizes the latest cell death-inducing DNA fragmentation factor 45-like effector protein discoveries related to the control of lipid metabolism, with emphasis on the role of these proteins in lipid droplet growth in adipocytes and in the regulation of very low-density lipoprotein lipidation and maturation in hepatocytes. (Arterioscler Thromb Vasc Biol. 2012; 32: 1094-1098.)