Mediators and mechanisms associated with paroxysm in Plasmodium vivax malaria
Mediators and mechanisms associated with paroxysm in Plasmodium vivax malaria
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DOI：
10.1111/j.2042-7158.1997.tb06158.x
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发表时间：
1997-04-01
影响因子：
3.3
通讯作者：
Mendis, KN
中科院分区：
文献类型：
--
作者：
Carter, R;Wijesekera, SK;Mendis, KN
描述了间日疟原虫疟疾发作的症状，然后总结了已知的症状的原因，并讨论了发作的生物学意义;简要描述了几个实验，其中一些已经在以前的出版物中报道过。基于这些结果，作者得出结论，发作患者的血浆（但不是从发作前或发作后不久的患者中采集的血浆）使P失活。vivaxgametocytes，这种影响不仅仅是由于温度。单核细胞、肿瘤坏死因子α和寄生虫产物对于这种灭活都是必要的，但不是充分的。这种作用是由一氧化氮（NO）介导的。白细胞介素-2和粒细胞-巨噬细胞集落刺激因子都是必需的。寄生虫产物在抗原性上是不同的，并且对寄生虫物种是特异性的。这些研究结果的影响的机制，其中阵发性灭活寄生虫进行了讨论，它的结论是，抗原特异性T细胞和物种特异性抗原参与，并在一个图表中提出了一个计划的过程。
The symptoms of the paroxysms ofPlasmodium vivaxmalaria are described, followed by a summary of what is known about the cause of the symptoms and a discussion of the biological significance of the paroxysm; several experiments, some already reported in previous publications, are briefly described. Based on these results, the authors conclude that the plasma of paroxysmal patients (but not that taken from patients shortly before or after a paroxysm) inactivatesP. vivaxgametocytes, and that this effect is not solely due to temperature. Monocytes, tumour necrosis factor α and parasite products are all necessary but not sufficient for this inactivation. The effect is mediated by nitric oxide (NO). Interleukin-2 and granulocyte-macrophage-colony stimulating factor are both necessary. The parasite products are antigenically distinct and specific to the parasite species. The implications of these findings for the mechanism by which the paroxysm inactivates parasites are discussed; it is concluded that antigen-specific T cells and species-specific antigens are involved, and a scheme for the process is presented in a diagram.