Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement
Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement
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DOI：
10.1016/j.biomaterials.2005.06.003
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发表时间：
2006-01-01
期刊：
影响因子：
14
通讯作者：
Marcolongo, M
中科院分区：
文献类型：
--
作者：
Joshi, A;Fussell, G;Marcolongo, M
作为当前下背痛治疗的替代方案的新兴技术包括人工材料的髓核置换，其目的是缓解疼痛并恢复正常的脊柱运动。本文研究了PVA/PVP水凝胶髓核植入体的压缩力学性能。水凝胶在无约束和约束条件下静态加载。对水凝胶进行了高达1000万次压缩疲劳循环的动态测试。此外，将具有线对线拟合的水凝胶髓核植入物植入人尸体椎间盘（IVD）中，以确定植入椎间盘的压缩行为。水凝胶样品在无侧限和有侧限压缩下均表现出典型的非线性响应。限制环的性质决定了所观察到的响应。水凝胶模量和聚合物含量在疲劳前后没有不同。疲劳后观察到轻微几何变化（大部分可恢复）。在尸体中，水凝胶恢复的压缩刚度的去核椎间盘相比，相当于条件的IVD.The研究结果表明，PVA/PVP水凝胶可能是可行的髓核植入物。在复杂载荷条件下的进一步研究是必要的，以更好地评估其作为退变髓核替代物的潜力。(c)2005爱思唯尔有限公司保留所有权利。
Emerging techniques as an alternative to the current treatments of lower back pain include nucleus replacement by an artificial material, which aims to relieve pain and restore the normal spinal motion. The compressive mechanical behavior of the PVA/PVP hydrogel nucleus implant was assessed in the present study.PVA/PVP hydrogels were made with various PVP concentrations. The hydrogels were loaded statically under unconfined and confined conditions. Hydrogels were tested dynamically up to 10 million cycles for a compression fatigue. Also, hydrogel nucleus implants with a line-to-line fit, were implanted in the human cadaveric intervertebral discs (IVD) to determine the compressional behavior of the implanted discs. Hydrogel samples exhibited typical non-linear response under both unconfined and confined compressions. Properties of the confinement ring dictated the observed response.Hydrogel moduli and polymer content were not different pre- and post-fatigues. Slight geometrical changes (mostly recoverable) were observed post-fatigue. In cadavers, hydrogels restored the compressive stiffness of the denucleated disc when compared with equivalent condition of the IVD.The results of this study demonstrate that PVA/PVP hydrogels may be viable as nucleus pulposus implants. Further studies under complex loading conditions are warranted to better assess its potential as a replacement to the degenerated nucleus pulposus. (c) 2005 Elsevier Ltd. All rights reserved.