Fabric dependence of bone ultrasound.
Fabric dependence of bone ultrasound.
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发表时间：
2010
影响因子：
1
通讯作者：
S. Cowin;L. Cardoso
中科院分区：
文献类型：
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作者：
S. Cowin;L. Cardoso
目前对骨丢失和骨质疏松症的诊断是基于骨矿物质密度(BMD)或表观质量密度的测量。遗憾的是，在大多数临床超声密度计中：1)测量通常是在单个解剖方向上执行的，2)仅对到达超声探头的第一个波进行表征，以及3)骨状态的分析基于可测量量之间的经验关系，如声速(SOS)和宽带超声衰减(BUA)与多孔介质的密度。然而，已有报道称松质骨中存在第二波，这是Biot的孔弹性波传播理论所预测的孔弹性介质的明确特征。我们采用了一种基于组构的各向异性孔弹性方法作为理论框架来描述可测量的波特性与骨小梁弹性常数之间的微结构依赖关系，从而为骨质量评估提供了一种超越单纯BMD的替代方法。
Current diagnosis of bone loss and osteoporosis is based on the measurement of the Bone Mineral Density (BMD) or the apparent mass density. Unfortunately, in most clinical ultrasound densitometers: 1) measurements are often performed in a single anatomical direction, 2) only the first wave arriving to the ultrasound probe is characterized, and 3) the analysis of bone status is based on empirical relationships between measurable quantities such as Speed of Sound (SOS) and Broadband Ultrasound Attenuation (BUA) and the density of the porous medium. However, the existence of a second wave in cancellous bone has been reported, which is an unequivocal signature of poroelastic media, as predicted by Biot's poroelastic wave propagation theory. A fabric-dependent anisotropic poroelastic approach is empolyed as a theoretical framework to describe the microarchitectural-dependent relationship between measurable wave properties and the elastic constants of trabecular bone, and thus represents an alternative for bone quality assessment beyond BMD alone.