MICROVESSEL COUNT PREDICTS METASTATIC DISEASE AND SURVIVAL IN NON-SMALL-CELL LUNG-CANCER
MICROVESSEL COUNT PREDICTS METASTATIC DISEASE AND SURVIVAL IN NON-SMALL-CELL LUNG-CANCER
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DOI：
10.1002/path.1711770110
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发表时间：
1995-09-01
影响因子：
7.3
通讯作者：
BEVILACQUA, G
中科院分区：
文献类型：
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作者：
FONTANINI, G;BIGINI, D;BEVILACQUA, G
新生血管的生长或新生血管生成是生理和病理的一个重要步骤：特别是肿瘤的生长和转移需要血管生成。微血管计数（MC）是衡量肿瘤血管生成的一个指标，它与皮肤、乳腺、前列腺、头颈部和早期肺癌的转移性扩散有关。本研究对253例原发性非小细胞肺癌（NSCLC）患者进行了肿瘤血管生成作为预后指标的研究。用抗VIII因子单克隆抗体（MAb）对固定肿瘤样本中的内皮细胞进行高亮显示，计数微血管。单变量分析中，MC (P
The growth of newly formed vessels, or neoangiogenesis, represents an important step in both physiological and pathological situations: in particular, tumour growth and metastasis require angiogenesis. Microvessel count (MC), which represents a measure of tumour angiogenesis, has been associated with metastatic spread in cutaneous, mammary, prostatic, head and neck, and early-stage lung cancer. In this study, the role of tumour angiogenesis as a prognostic indicator was examined in 253 primary non-small cell lung cancer (NSCLC) patients. Microvessels were counted by highlighting endothelial cells with anti-Factor VIII monoclonal antibody (MAb) in methacarn-fixed tumour samples. In univariat analysis, MC (P