Antischistosomal Activity of Oxindolimine-Metal Complexes
Antischistosomal Activity of Oxindolimine-Metal Complexes
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DOI：
10.1128/aac.01371-15
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发表时间：
2015-10-01
影响因子：
4.9
通讯作者：
da Costa Ferreira, Ana M.
中科院分区：
文献类型：
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作者：
de Moraes, Josue;Dario, Bruno S.;da Costa Ferreira, Ana M.
近年来，已经报道了一类羟吲哚-铜和羟吲哚-锌络合物衍生物作为对不同肿瘤细胞（例如，神经母细胞瘤、黑素瘤、单核细胞）。在这里，我们评估了合成的羟吲哚铜（II），锌（II），和钒（VO 2+）配合物对成人曼氏血吸虫蠕虫的疗效。铜（II）络合物（50%抑制浓度为30至45 μ M）表现出更大的抗雌激素体的性质比类似的锌和钒络合物的致死率，减少运动活动，产卵。
In recent years, a class of oxindole-copper and -zinc complex derivatives have been reported as compounds with efficient proapoptotic activity toward different tumor cells (e.g., neuroblastomas, melanomas, monocytes). Here we assessed the efficacy of synthesized oxindole-copper(II), -zinc(II), and -vanadyl (VO2+) complexes against adult Schistosoma mansoni worms. The copper( II) complexes (50% inhibitory concentrations of 30 to 45 mu M) demonstrated greater antischistosomal properties than the analogous zinc and vanadyl complexes regarding lethality, reduction of motor activity, and oviposition.