Cognitive functioning in siblings discordant for schizophrenia
Cognitive functioning in siblings discordant for schizophrenia
复制标题
DOI：
10.1111/j.1600-0447.2004.00392.x
复制
发表时间：
2005-03-01
影响因子：
6.7
通讯作者：
Sharma, T
中科院分区：
文献类型：
--
作者：
Hughes, C;Kumari, V;Sharma, T
目的：通过对25例精神分裂症患者、25例正常兄弟姐妹和25例健康对照的持续注意、记忆和学习、执行功能、视觉空间能力和精神运动功能的神经心理学测试，探讨神经心理损害作为精神分裂症的遗传危险指标和兄弟姐妹中分裂体征/症状的发生率。结果：在记忆、学习和执行功能的某些指标上，未受影响的兄弟姐妹比患者表现得更好。患者和兄弟姐妹表现出全面智商和语言流畅性受损，其他兄弟姐妹的表现与健康对照组相似。控制智商的差异，言语流畅性的共同缺陷消失。结论：精神分裂症患者和未受影响的兄弟姐妹(没有分裂型人格障碍)在言语流畅性方面存在神经心理缺陷。这一缺陷似乎是由智商调节的。区分患者和对照组的缺陷可能不是遗传的，可能与精神分裂症的表现或治疗有关。
Objective: The objective of this study was to investigate neuropsychological impairment as a genetically mediated risk indicator for schizophrenia while accounting for prevalence of schizotypy signs/symptoms in siblings.Method: Cognitive functioning in 25 individuals with schizophrenia, 25 unaffected siblings and 25 unrelated healthy controls, was assessed using neuropsychological tests of sustained attention, memory and learning, executive function, visual-spatial ability and psychomotor performance.Results: Unaffected siblings demonstrated better performance than patients on some measures of memory and learning and executive function. Patients and siblings demonstrated impaired Full Scale IQ and verbal fluency, otherwise siblings performed similarly to healthy controls. Controlling for differences in IQ, the shared deficit in verbal fluency disappeared.Conclusion: Patients with schizophrenia and unaffected siblings (without schizotypy personality disorder) shared a neuropsychological deficit in verbal fluency. This deficit appeared to be mediated by IQ. Deficits, which differentiated patients from controls, may not be inherited and perhaps are related to the manifestation or treatment of schizophrenia.