Hunting for neuronal currents: absence of rapid MRI signal changes during visual-evoked response
Hunting for neuronal currents: absence of rapid MRI signal changes during visual-evoked response
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DOI：
10.1016/j.neuroimage.2004.07.003
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发表时间：
2004-11-01
期刊：
影响因子：
5.7
通讯作者：
Duyn, JH
中科院分区：
文献类型：
--
作者：
Chu, RN;de Zwart, JA;Duyn, JH
虽然最近的报告主张使用磁共振成像（MRI）来检测与人脑活动相关的神经元电流的影响，但到目前为止，只有初步的实验数据证明了该方法的可行性。此外，尚未充分证明（1）MRI可以将神经元电流（NC）效应与其他效应（如血氧水平依赖性（BOLD）对比度）分开;（2）MRI具有足够的灵敏度来检测体内NC。在这项工作中，我们介绍了一种方法，可以分离缓慢（例如，BOLD）过程从潜在的快速（例如，NC）处理并应用该方法来研究MRI是否允许检测对视觉刺激的NC响应。在3.0 T下使用灵敏的多通道探测器进行的MRI研究（n = 8）显示，在存在高度显著的BOLD信号（Q = 6.15 +/- 0.90）的情况下，与NC相关的影响不显著（平均t < 0.05）。相比之下，在类似条件下对相同受试者进行的脑磁图（MEG）实验显示出非常显着的电活动（Q = 7.90 +/- 2.28）。它的结论是，在本研究中使用的条件下，MRI检测诱发反应通过NC的灵敏度是至少一个数量级低于BOLD为基础的功能性MRI（fMRI）或MEG和太低，实际上是有用的。爱思唯尔公司出版
While recent reports have advocated the use of magnetic resonance imaging (MRI) to detect the effects of neuronal currents associated with human brain activity, only preliminary experimental data have been presented so far to demonstrate the feasibility of the method. Furthermore, it has not been adequately demonstrated that (1) MRI can separate neuronal current (NC) effects from other effects such as blood oxygen level-dependent (BOLD) contrast; (2) MRI has adequate sensitivity to detect NCs in vivo. In this work, we introduce a method that can separate slow (e.g., BOLD) processes from potential rapid (e.g., NC) processes and apply this method to investigate whether MRI allows detection of an NC response to a visual stimulus. MRI studies (n = 8) at 3.0 T using a sensitive multichannel detector showed insignificant effects related to NCs (averaged t < 0.05), in the presence of a highly significant BOLD signal Q = 6.15 +/- 0.90). In contrast, magnetoencephalography (MEG) experiments performed under similar conditions on the same subjects showed highly significant electrical activity Q = 7.90 +/- 2.28). It is concluded that, under the conditions used in this study, the sensitivity of MRI to detect evoked responses through NCs is at least an order of magnitude below that of BOLD-based functional MRI (fMRI) or MEG and too low to be practically useful. Published by Elsevier Inc.