Enteroviruses in Spain over the decade 1998-2007: Virological and epidemiological studies
Enteroviruses in Spain over the decade 1998-2007: Virological and epidemiological studies
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DOI：
10.1016/j.jcv.2009.11.013
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发表时间：
2010-02-01
影响因子：
8.8
通讯作者：
Cabrerizo, M.
中科院分区：
文献类型：
--
作者：
Trallero, G.;Avellon, A.;Cabrerizo, M.
背景资料：人类肠道病毒（HEV）是病毒性脑膜炎和其他疾病的最常见病因，因此HEV的特征在患者管理和流行病学调查中都很重要。目的：在西班牙进行了一项为期10年的肠道病毒感染患者研究，以确定潜在的病因。研究设计：通过微量中和试验和/或分子方法对HEV进行完全分型。结果：在西班牙的几个实验室收集了86404份临床样本进行了研究。这些样本来自不同综合征的患者，主要是无菌性脑膜炎（AM）、发热、呼吸道疾病和急性弛缓性麻痹。其中，获得了6867个HEV。在国家脊髓灰质炎病毒实验室，对2814例进行了血清学表征。在非小儿麻痹症肠道病毒中，8种主要血清型为埃可病毒30型（25%）、埃可病毒6型（12.4%）、埃可病毒13型（8.3%）、埃可病毒11型（7.4%）和埃可病毒9型（4.7%），其次为柯萨奇病毒B5型（4.2%）、埃可病毒7型和柯萨奇病毒A9型（各3.7%）。在AM病例中，在39%的病例中鉴定出Echovirus 30，其次是Echovirus 6（14%）。然而，埃可病毒6主要与呼吸道疾病相关（17%），其次是埃可病毒11（10%）。另一方面，Echovirus 30、Echovirus 11和Echovirus 6在发热病例中各占12%。(13))西班牙1998 ~ 2007年HEV发病率的调查结果。本研究中描述的监测提供了有价值的信息，如血清型在循环中，新的戊型肝炎病毒的出现和与临床表现的关联。(C)2009年由Elsevier B. V.出版
Background: Human enteroviruses (HEV) are the commonest cause of viral meningitis as well as other pathologies, therefore HEV characterization is important both in patient management and epidemiological investigation.Objectives: A 10-year study of patients with enteroviral infection was carried out in Spain to determine the underlying etiology.Study design: HEV were fully typed by microneutralisation tests and/or molecular methods.Results: A collection of 86404 clinical samples were studied in several Spanish laboratories. These were collected from patients with different syndromes, mainly aseptic meningitis (AM), fever, respiratory diseases and acute flaccid paralysis. Of these, 6867 HEV were obtained. At the National Poliovirus Laboratory 2814 were serotypically characterised. Among non-polio enteroviruses, the eight main serotypes were Echovirus 30 (25%), Echovirus 6 (12.4%), Echovirus 13 (8.3%), Echovirus 11 (7.4%) and Echovirus 9 (4.7%), followed by Coxsackievirus B5 (4.2%) and Echovirus 7 and Coxsackievirus A9 (3.7%) each. In AM cases, Echovirus 30 was identified in 39% of them, followed by Echovirus 6 (14%). However, Echovirus 6 was mainly associated with respiratory disease (17%), followed by Echovirus 11 (10%). On the other hand, Echovirus 30, Echovirus 11 and Echovirus 6 contributed equally with 12% of each serotype in the cases of fever.Conclusions: The present report complements previous data (Trallero et al.(13)), with the results of HEV incidence in Spain from 1998 to 2007. The surveillance described in this study provided valuable information as to which serotypes are in circulation, the emergence of new HEV and association with clinical manifestations. (C) 2009 Published by Elsevier B.V.