Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus
Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus
复制标题
系统性红斑狼疮血清白介素19水平及单核苷酸多态性分析
DOI：
10.4238/gmr.15028007
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发表时间：
2016-01-01
影响因子：
0.4
通讯作者：
Xu, J. H.
中科院分区：
文献类型：
--
作者：
Lin, J. R.;Qin, H. H.;Xu, J. H.
系统性红斑狼疮(SLE)是一种自身免疫性结缔组织病，累及多个器官，降低患者的生活质量。白介素19(IL19)参与细胞间信号转导，与免疫反应和局部炎症反应有关。单核苷酸多态(SNPs)已被用来探索SLE发病的遗传基础。在本研究中，我们研究了功能性IL19 SNP rs2243188与SLE的潜在相关性。在SLE人群中，rs2243188等位基因C的频率较低，尤其是在应用显性遗传模型时。在显性遗传模式和隐性遗传模式中，狼疮性肾炎(LN)组和非LN组之间的等位基因C频率也有显著差异。此外，我们还发现不同类型的SLE患者的血清IL-19水平存在显著差异。虽然本研究尚处于初步阶段，但IL-19基因SNP与SLE的相关性以及IL-19水平与SLE不同亚型之间的相关性为进一步探讨提供了参考。
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and diminishes a patients' quality of life. It has been suggested that interleukin 19 (IL19) is engaged in intercellular signal transduction, which is related to the immune response and the local inflammatory reaction. Single nucleotide polymorphisms (SNPs) have been used to explore the genetic basis underlying the pathogenesis of SLE. In this study, we investigated the potential correlation between the functional IL19 SNP rs2243188 and SLE. The frequency of allele C in rs2243188 was lower in the SLE population, particularly when the dominant inheritance model was applied. There was also a significant difference in the allele C frequency between the lupus nephritis (LN) and non-LN groups in both the dominant and recessive inheritance models. In addition, we identified significant differences in the serum IL-19 levels between the different classes of SLE. Although this study is still at the preliminary stage, the correlations between the IL19 SNP and SLE, and between the IL-19 levels and the different subclasses of SLE provide a reference for further exploration.