EFFECTS OF HYPERCAPNIA AND ARTERIAL-HYPOTENSION AND HYPERTENSION ON CEREBROSPINAL-FLUID PULSE PRESSURE AND INTRA-CRANICAL VOLUME-PRESSURE RELATIONSHIPS
EFFECTS OF HYPERCAPNIA AND ARTERIAL-HYPOTENSION AND HYPERTENSION ON CEREBROSPINAL-FLUID PULSE PRESSURE AND INTRA-CRANICAL VOLUME-PRESSURE RELATIONSHIPS
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DOI：
10.1136/jnnp.43.3.222
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发表时间：
1980-01-01
影响因子：
11
通讯作者：
WYPER, DJ
中科院分区：
文献类型：
--
作者：
AVEZAAT, CJJ;VANEIJNDHOVEN, JHM;WYPER, DJ
在 12 只麻醉、通气的狗中，在幕上硬膜外球囊持续充气期间，研究了高碳酸血症和药物诱导的动脉低血压和高血压对容量压力反应 (VPR) 和脑脊液脉压之间相互关系的影响。高碳酸血症并没有显着影响颅内容积-压力关系，但确实导致脑脊液脉压和颅内压（ICP）之间关系的梯度显着增加。动脉血压的变化对 VPR 和 CSF 脉压显示出相反的影响。动脉低血压期间观察到 VPR 降低和脉压升高；在动脉高血压期间发现了相反的情况。 VPR 和 CSF 脉压变量的影响之间的差异可以通过每个心动周期脑血容量短暂增加的变化来解释。在临床 ICP 监测过程中，可以通过颅内容积-压力关系的变化来解释 CSF 脉压与 ICP 比率的变化。
In 12 anesthetized, ventilated dogs the effects of hypercapnia and pharmacologically induced arterial hypotension and hypertension on the interrelation between volume-pressure response (VPR) and CSF pulse pressure were studied during continuous inflation of a supratentorial extradural balloon. Hypercapnia did not significantly affect the intracranial volume-pressure relationships, but did cause a significant increase in gradient of the relationship between CSF pulse pressure and intracranial pressure (ICP). Alteration of the arterial blood pressure showed opposite effects on VPR and CSF pulse pressure. A decrease in VPR and an increase in pulse pressure were observed during arterial hypotension; the reverse was found during arterial hypertension. The discrepancy between the effects of VPR and CSF pulse pressure of the variables was explained by changes in the transient increase in cerebral blood volume per cardiac cycle. During clinical ICP monitoring the interpretation of changes in the CSF pulse pressure to ICP ratio by changes in intracranial volume-pressure relationships is made possible.