Enhanced experimental metastasis of ultraviolet light-induced fibrosarcomas in ultraviolet light-irradiated syngeneic mice.
Enhanced experimental metastasis of ultraviolet light-induced fibrosarcomas in ultraviolet light-irradiated syngeneic mice.
复制标题
紫外线照射的同基因小鼠中紫外线诱导的纤维肉瘤的实验性转移增强。
作者：
M. Kripke;Isaiah J. Fidler
一些紫外线（UV）诱导的纤维肉瘤产生更多的实验性肺肿瘤集落在紫外线照射的主机比正常的同基因受体。静脉注射这些肿瘤后产生的实验性转移的数量与UV辐射的剂量成比例地增加。这种增强作用可以通过淋巴细胞转移到致死性X射线照射的受体，并通过部分纯化的T淋巴细胞转移到未经处理的同基因小鼠。一些紫外线诱导的纤维肉瘤不容易形成实验性转移，即使在紫外线照射的收件人，这表明免疫和非免疫因素是重要的限制转移形成。
Some ultraviolet light (UV)-induced fibrosarcomas produce more experimental pulmonary tumor colonies in UV-irradiated hosts than in normal syngeneic recipients. The number of experimental metastases produced following i.v. injection of these tumors increases in proportion to the dose of UV radiation. This enhancement can be transferred with lymphoid cells to lethally X-irradiated recipients and with partially purified T-lymphocytes to untreated syngeneic mice. Some UV-induced fibrosarcomas do not form experimental metastases readily, even in UV-irradiated recipients, suggesting that both immunological and nonimmunological factors are important in limiting metastasis formation.