Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission.
Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission.
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DOI：
10.3389/fncel.2012.00005
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发表时间：
2012
影响因子：
5.3
通讯作者：
Lévi S
中科院分区：
文献类型：
--
作者：
Chamma I;Chevy Q;Poncer JC;Lévi S
K-Cl共转运体KCC2在中枢神经元的生理中起着多种作用，其功能和/或表达的改变与几种神经系统疾病有关。通过调节神经元内氯离子稳态，KCC2强烈影响氯离子可渗透γ-氨基丁酸（GABA） A型和甘氨酸受体（GlyR）介导的突触传递的有效性和极性。这对于神经元回路的发育以及成熟网络中GABA和甘氨酸信号的动态控制显得尤为重要。转运体的活性也与跨膜水通量有关，而跨膜水通量补偿与突触活性相关的溶质通量。最后，KCC2与肌动蛋白细胞骨架的相互作用似乎对树突棘的形态发生和谷氨酸突触的维持都至关重要。鉴于KCC2在中枢突触成熟和功能中的关键作用，了解其调控的细胞和分子机制尤为重要。这些包括转录和翻译后水平上的发育和活性依赖性修饰。我们强调翻译后机制的重要性，如磷酸化和去磷酸化、寡聚化、细胞表面稳定性、聚类和膜扩散对KCC2功能的快速和动态调节。
The K-Cl co-transporter KCC2 plays multiple roles in the physiology of central neurons and alterations of its function and/or expression are associated with several neurological conditions. By regulating intraneuronal chloride homeostasis, KCC2 strongly influences the efficacy and polarity of the chloride-permeable γ-aminobutyric acid (GABA) type A and glycine receptor (GlyR) mediated synaptic transmission. This appears particularly critical for the development of neuronal circuits as well as for the dynamic control of GABA and glycine signaling in mature networks. The activity of the transporter is also associated with transmembrane water fluxes which compensate solute fluxes associated with synaptic activity. Finally, KCC2 interaction with the actin cytoskeleton appears critical both for dendritic spine morphogenesis and the maintenance of glutamatergic synapses. In light of the pivotal role of KCC2 in the maturation and function of central synapses, it is of particular importance to understand the cellular and molecular mechanisms underlying its regulation. These include development and activity-dependent modifications both at the transcriptional and post-translational levels. We emphasize the importance of post-translational mechanisms such as phosphorylation and dephosphorylation, oligomerization, cell surface stability, clustering and membrane diffusion for the rapid and dynamic regulation of KCC2 function.
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影响因子：
5.5
作者：
Chudotvorova, I;Ivanov, A;Medina, I
通讯作者：
Medina, I
影响因子：
5.1
作者：
Cherubini, Enrico;Griguoli, Marilena;Lagostena, Laura
通讯作者：
Lagostena, Laura
影响因子：
5.3
作者：
Cancedda, Laura;Fiumelli, Hubert;Poo, Mu-ming
通讯作者：
Poo, Mu-ming
通过MZNR/GPR39受体对KCC2活性的上调。
DOI：
10.1523/jneurosci.2205-11.2011
发表时间：
2011-09-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chorin E;Vinograd O;Fleidervish I;Gilad D;Herrmann S;Sekler I;Aizenman E;Hershfinkel M
通讯作者：
Hershfinkel M
影响因子：
5.3
作者：
Banke, Tue G.;McBain, Chris J.
通讯作者：
McBain, Chris J.