Synthesis of the bicyclic core of the nucleoside antibiotic octosyl acid A.
Synthesis of the bicyclic core of the nucleoside antibiotic octosyl acid A.
复制标题
核苷类抗生素辛基酸 A 的双环核心的合成。
DOI：
10.1021/jo052025s
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Finney,NathanielS
中科院分区：
文献类型：
--
作者：
More,JesseD;Finney,NathanielS
以非对映选择性乙炔加成和6-内硒醚化为关键步骤，合成了具有双环结构的N-乙酰基-2-甲基-3-苯磺酸A。详细研究了硒醚化反应，并讨论了将苯基转化为羧酸时遇到的困难。
The bicyclic core of octosyl acid A has been prepared using a diastereoselective acetylide addition and 6-endo selenoetherification as key steps. A detailed study of the selenoetherification reaction and difficulties encountered in the conversion of a phenyl group to a carboxylic acid will be discussed.