Human embryo implantation.
Human embryo implantation.
复制标题
人类胚胎植入。
DOI：
10.1242/dev.201507
复制
发表时间：
2023-05-15
期刊：
影响因子：
4.6
通讯作者：
Brosens, Jan J.
中科院分区：
文献类型：
--
作者：
Muter, Joanne;Lynch, Vincent J.;McCoy, Rajiv C.;Brosens, Jan J.
人类的胚胎植入是间质的，这意味着在胎盘滋养细胞侵入子宫粘膜以外的子宫内肌层之前，整个胚胎都会嵌入子宫内膜。一旦植入，胚胎存活的关键是在子宫自然杀伤细胞的动态平衡控制下，将子宫内膜转变为抗炎的胎盘床，称为蜕膜。在这里，我们研究胚胎植入的进化背景，并详细阐述人类受孕前后的子宫重塑。我们还讨论了胚胎和蜕膜化子宫内膜之间的相互作用，它们调节间质植入并决定胚胎的适合性。总而言之，本审查突出了植入过程的不稳定但可适应的性质。摘要：本综述从进化论的角度考察了妊娠的基本过程，强调了允许植入的子宫重塑，并研究了胚胎适合性对子宫内膜动态平衡的影响。
Embryo implantation in humans is interstitial, meaning the entire conceptus embeds in the endometrium before the placental trophoblast invades beyond the uterine mucosa into the underlying inner myometrium. Once implanted, embryo survival pivots on the transformation of the endometrium into an anti-inflammatory placental bed, termed decidua, under homeostatic control of uterine natural killer cells. Here, we examine the evolutionary context of embryo implantation and elaborate on uterine remodelling before and after conception in humans. We also discuss the interactions between the embryo and the decidualising endometrium that regulate interstitial implantation and determine embryo fitness. Together, this Review highlights the precarious but adaptable nature of the implantation process. Summary: This Review examines the foundational processes of pregnancy from an evolutionary perspective, highlights uterine remodelling permissive for implantation, and examines the impact of embryo fitness on endometrial homeostasis.