A functionalized graphene oxide-iron oxide nanocomposite for magnetically targeted drug delivery, photothermal therapy, and magnetic resonance imaging
A functionalized graphene oxide-iron oxide nanocomposite for magnetically targeted drug delivery, photothermal therapy, and magnetic resonance imaging
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用于磁靶向药物输送、光热疗法和磁共振成像的功能化氧化石墨烯-氧化铁纳米复合材料
DOI：
10.1007/s12274-012-0200-y
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发表时间：
2012-03-01
期刊：
影响因子：
9.9
通讯作者：
Liu, Zhuang
中科院分区：
文献类型：
--
作者：
Ma, Xinxing;Tao, Huiquan;Liu, Zhuang
二维石墨烯及其复合纳米材料具有有趣的物理/化学性质，近年来在各个领域得到了广泛的探索。在这项工作中，我们合成了一种多功能超顺磁性氧化石墨烯-氧化铁杂化纳米复合材料（GO-IONP），然后通过生物相容性聚乙二醇（PEG）聚合物对其进行功能化，以在生理溶液中获得高稳定性。将化疗药物阿霉素 (DOX) 负载到 GO-IONP-PEG 上，形成 GO-IONP-PEG-DOX 复合物，从而实现磁性靶向药物递送。 GO-IONP-PEG 还表现出从可见光到近红外 (NIR) 区域的强光吸收，可用于在磁场引导下对癌细胞进行局部光热消融。此外，还首次使用GO-IONP-PEG作为T（2）造影剂对荷瘤小鼠进行体内磁共振（MR）成像。我们的工作表明了基于 GO 的多功能纳米复合材料在癌症治疗诊断中的应用前景。
Two-dimensional graphene and its composite nanomaterials offer interesting physical/chemical properties and have been extensively explored in a wide range of fields in recent years. In this work, we synthesize a multi-functional superparamagnetic graphene oxide-iron oxide hybrid nanocomposite (GO-IONP), which is then functionalized by a biocompatible polyethylene glycol (PEG) polymer to acquire high stability in physiological solutions. A chemotherapy drug, doxorubicin (DOX), was loaded onto GO-IONP-PEG, forming a GO-IONP-PEG-DOX complex, which enables magnetically targeted drug delivery. GO-IONP-PEG also exhibits strong optical absorbance from the visible to the near-infrared (NIR) region, and can be utilized for localized photothermal ablation of cancer cells guided by the magnetic field. Moreover, for the first time, in vivo magnetic resonance (MR) imaging of tumor-bearing mice is also demonstrated using GO-IONP-PEG as the T (2) contrast agent. Our work suggests the promise of using multifunctional GO-based nanocomposites for applications in cancer theranostics.