Segmental Tandem Triplication of the MLL Gene in an Intravascular Large B-Cell Lymphoma With Multisystem Involvement A Comprehensive Morphologic, Immunophenotypic, Cytogenetic, and Molecular Cytogenetic Antemortem Study
Segmental Tandem Triplication of the MLL Gene in an Intravascular Large B-Cell Lymphoma With Multisystem Involvement A Comprehensive Morphologic, Immunophenotypic, Cytogenetic, and Molecular Cytogenetic Antemortem Study
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DOI：
10.1043/1543-2165-133.9.1477
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发表时间：
2009-09-01
影响因子：
4.6
通讯作者：
Wang, Huan-You
中科院分区：
文献类型：
--
作者：
Deisch, Jeremy;Fuda, Franklin 'Buddy';Wang, Huan-You
血管内大 B 细胞淋巴瘤 (IVLBCL) 与混合谱系白血病 (MLL) 基因之间的关联尚未得到证实。在这里，我们报告了一名 47 岁的亚洲男性患有 IVLBCL。从形态上看，非典型淋巴浸润完全局限于毛细血管腔、小血管和窦腔。在肾脏内，肿瘤性淋巴细胞表现出肾小球和肾小管周围毛细血管的分布模式。骨髓抽吸物的常规细胞遗传学分析显示出复杂的核型，在 11 号染色体的带段 q22-q25 处有显着的三重串联重复。对间期细胞和中期扩散进行的 MLL 探针组荧光原位杂交证实了衍生的 11 号染色体上存在 3 个 MLL 基因拷贝。从这一发现和文献中报道的其他 3 例 IVLBCL 病例中，我们得出结论，MLL 可能发挥作用至少在一部分病例中，其在 IVLBCL 的淋巴瘤发生中起重要作用。 （Arch Pathol 实验室医学。2009 年；133：1477-1482）
An association between intravascular large B-cell lymphoma (IVLBCL) and the mixed lineage leukemia (MLL) gene has never been demonstrated. Here, we report an IVLBCL in a 47-year-old Asian man. Morphologically, the atypical lymphoid infiltrate was entirely confined in the lumina of capillaries, small vessels, and sinusoidal space. Within the kidney, the neoplastic lymphoid cells exhibited both the glomerular and peritubular capillary distribution pattern. Conventional cytogenetic analysis from the bone marrow aspirates displayed a complex karyotype, with a notable triple tandem repeat at band segment q22-q25 of chromosome 11. Fluorescence in situ hybridization with an MLL probe set, performed on both interphase cells and metaphase spreads, confirmed the presence of 3 copies of the MLL gene on the derivative chromosome 11. From this finding and 3 other IVLBCL cases reported in the literature, we conclude that MLL may play an important role in the lymphomagenesis of IVLBCL at least in a subset of cases. (Arch Pathol Lab Med. 2009; 133: 1477-1482)