Advances in adipose tissue metabolism
Advances in adipose tissue metabolism
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DOI：
10.1038/ijo.2008.237
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发表时间：
2008-12-01
影响因子：
4.9
通讯作者：
Lafontan, M.
中科院分区：
文献类型：
--
作者：
Lafontan, M.
这篇综述将集中在脂肪组织代谢的最新发现，特别关注人类脂肪细胞的生物学和生理学。有重大进展源于从成熟的人脂肪细胞，人前脂肪细胞在体外分化和小鼠脂肪细胞系的研究中获得的伴随结果。生理学的发展是基于对各种小鼠转基因模型和生理学技术的广泛利用，如微透析、开放流微灌注、动静脉技术和利用氘或氚标记的代谢物，这些技术在理解人类脂肪组织生理学方面取得了许多生理学进展。基因表达谱研究和营养基因组学是新兴的方法，预示着未来有趣的方法。概述了最近发现的机制参与控制游离脂肪酸的摄取，三酰甘油的合成和脂肪沉积将进行讨论，以及最近的进展，在脂解途径，脂肪酶和perilipins的作用机制。此外，在体内验证的儿茶酚胺行动和利钠肽的脂解作用的发现也将包括在内。
This review will focus on the recent findings in adipose tissue metabolism with special attention to human adipocyte biology and physiology. There are major advances stemming from the concomitant results obtained from studies on mature human adipocytes, human preadipocytes differentiated in vitro and murine adipose cell lines. Physiological developments have been based on the expanded utilization of various kinds of murine transgenic models and physiological techniques such as microdialysis, open-flow microperfusion, arteriovenous techniques and the utilization of deuterium- or tritium-labelled metabolites that have provided a number of physiological advances in the understanding of human adipose tissue physiology. Gene expression profiling studies and nutrigenomics are emerging methods that herald interesting approaches for the future. An overview of recent discoveries in the mechanisms involved in the control of free fatty acid uptake, triacylglycerol synthesis and fat deposition will be discussed, as well as recent advances in the mechanisms involved in the lipolytic pathways, the role of lipases and perilipins. In addition, the in vivo validation of catecholamine action and the discovery of the lipolytic effects of natriuretic peptides will also be covered.