The dynamics of cyclin dependent kinase structure
The dynamics of cyclin dependent kinase structure
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DOI：
10.1016/s0955-0674(96)80076-7
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发表时间：
1996-12-01
影响因子：
7.5
通讯作者：
Morgan, DO
中科院分区：
文献类型：
--
作者：
Morgan, DO
在过去的一年里，一些新的晶体结构为调控细胞周期蛋白依赖性蛋白激酶的构象变化提供了令人兴奋的见解。我们现在了解了许多调控细胞周期蛋白依赖性激酶的机制的结构基础，包括通过细胞周期蛋白结合和磷酸化来激活，通过抑制p27来抑制，以及通过CKS蛋白结合。
In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition by the inhibitor p27, and binding by the CKS proteins.