Dermatitis herpetiformis: the skin and the gut.
Dermatitis herpetiformis: the skin and the gut.
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疱疹样皮炎：皮肤和肠道。
DOI：
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发表时间：
1980
影响因子：
39.2
通讯作者：
W. Strober
中科院分区：
文献类型：
--
作者：
S. Katz;R. Hall;T. Lawley;W. Strober
疱疹样皮炎是一种剧烈瘙痒的慢性丘疱疹，通常对称分布在伸肌表面。组织学上，其特征为真皮乳头状中性粒细胞聚集和表皮下囊泡形成。皮肤在与最早的组织病理学变化相对应的区域有 IgA 沉积；即在表皮-真皮交界处。大多数患者患有相关的无症状麸质敏感性肠病，其形态和对麸质蛋白的反应均与普通麸质敏感性肠病（乳糜泻）相似。这些患者中主要组织相容性抗原 HLA-B8 和 HLA-Dw3 以及某些 B 细胞抗原的患病率显着增加。尽管砜或磺胺吡啶一直是治疗的主要方法，但现在很明显，严格遵守无麸质饮食可以缓解皮肤病。对这些发现进行回顾，并从中得出关于疱疹样皮炎可能的病理生理机制的某些结论。
Dermatitis herpetiformis is an intensely itchy, chronic, papulovesicular eruption that is usually symmetrically distributed on extensor surfaces. Histologically, it is characterized by dermal papillary collections of neutrophils and subepidermal vesicle formation. The skin has IgA deposits in areas corresponding to the earliest histopathologic change; that is, at the epidermal-dermal junction. Most patients have an associated asymptomatic gluten-sensitive enteropathy that mimics ordinary gluten-sensitive enteropathy (celiac disease) both morphologically and in its response to gluten protein. There is a marked increase in the prevalence of the major histocompatibility antigens, HLA-B8 and HLA-Dw3, and in certain B cell antigens in these patients. Although the sulfones or sulfapyridine have been the mainstay of treatment, it is now clear that the skin disease responds to strict adherence to a gluten-free diet. These findings are reviewed and from them are drawn certain conclusions as to possible pathophysiologic mechanisms involved in dermatitis herpetiformis.
疱疹样皮炎的发病机制。
影响因子：
2.7
作者：
Otley,CC;Hall3rd,RP
通讯作者：
Hall3rd,RP