Prevalence and risk factors of suppurative complications in children with pneumonia
Prevalence and risk factors of suppurative complications in children with pneumonia
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DOI：
10.1111/j.1651-2227.2010.01734.x
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发表时间：
2010-06-01
期刊：
影响因子：
3.8
通讯作者：
Labarere, Jose
中科院分区：
文献类型：
--
作者：
Francois, Patrice;Desrumaux, Amelie;Labarere, Jose
目的：探讨社区获得性原发性肺炎患儿化脓性并发症的基线特征。方法：回顾性研究纳入1995年至2003年在法国两家医院出现社区获得性肺炎的所有28天至15岁儿童。并发肺炎的定义是出现脓胸和/或肺脓肿。结果：767例社区获得性肺炎患儿中出现化脓性并发症90例，其中胸膜脓肿83例，肺脓肿7例。在1995-1998年期间，复杂肺炎的平均患病率为3%，然后呈线性趋势稳步上升，2003年达到23%。并发肺炎患儿年龄较大，住院前症状期较长。他们更有可能接受抗生素，尤其是氨基霉素（p < 0.01）和非甾体抗炎药，尤其是布洛芬（p < 0.001）。在多变量分析中，布洛芬是唯一与合并肺炎独立相关的入院前治疗[校正OR = 2.57(1.51-4.35)]。结论：本研究证实院前使用布洛芬与化脓性肺炎并发症之间存在关联。
Aim:To identify the baseline characteristics associated with suppurative complications in children with community-acquired primary pneumonia.Methods:A retrospective study included all children from 28 days to 15 years old, who presented with community-acquired pneumonia at two French hospitals from 1995 to 2003. Complicated pneumonia was defined by the presence of empyema and/or lung abscess.Results:Of 767 children with community-acquired pneumonia, 90 had suppurative complications: 83 cases of pleural empyema and seven cases of lung abscess. The mean prevalence of complicated pneumonia was 3% during the 1995-1998 period, and then steadily increased following a linear trend to reach 23% in 2003. Children with complicated pneumonia were older and had a longer symptomatic period preceding hospitalization. They were more likely to receive antibiotics, especially aminopenicillins (p < 0.01), and nonsteroidal anti-inflammatory drugs, especially ibuprofen (p < 0.001). In multivariable analysis, ibuprofen was the only preadmission therapy that was independently associated with complicated pneumonia [adjusted OR = 2.57 (1.51-4.35)].Conclusion:This study confirms an association between the use of prehospital ibruprofen and suppurative pneumonic complications.