THE CANNABINOIDS AS POTENTIAL ANTIEPILEPTICS
THE CANNABINOIDS AS POTENTIAL ANTIEPILEPTICS
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DOI：
10.1002/j.1552-4604.1981.tb02624.x
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发表时间：
1981-01-01
影响因子：
2.9
通讯作者：
TURKANIS, SA
中科院分区：
文献类型：
--
作者：
KARLER, R;TURKANIS, SA
在许多动物癫痫发作模型中对大麻素和原型抗癫痫药物的抗惊厥特性的比较研究表明：（1）作为抗惊厥剂，大麻二酚（CBD）与Δ9-四氢大麻酚（THC）相比，在中枢神经系统（CNS）兴奋和兴奋特性方面具有相对选择性;（2）与苯妥英和苯巴比妥不同，大麻二酚的效力因物种而异;（3）小鼠中大麻素和抗癫痫药之间的大的效力差异似乎是由于性格差异，因为所有药物的脑浓度非常相似;（4）对大麻二酚的抗惊厥特性的耐受性不是显著特征;在三种癫痫发作模型中，一种产生了耐受性，但另两种产生了“反向耐受性”;以及（5）电生理学作用机制的研究结果表明，大麻二酚产生一些独特的作用，原型药物大麻二酚的抗惊厥性质表明，它对四种主要类型的癫痫中的至少三种具有治疗潜力：大发作，皮质局灶性和复杂部分性癫痫发作。
Comparative studies of the anticonvulsant properties of the cannabinoids and prototype antiepileptic drugs in numerous animal seizure models demonstrate that (1) as an anticonvulsant, cannabidiol (CBD), in contrast to Δ9‐tetrahydrocannabinol (THC), is relatively selective in terms of both central nervous system (CNS) depressant and excitatory properties; (2) the potency of cannabidiol, unlike that of phenytoin and phenobarbital, varies greatly with the species; (3) the large potency difference between the cannabinoids and the antiepileptics in the mouse appears to be due to dispositional differences, because brain concentrations of all the drugs are very similar; (4) tolerance to the anticonvulsant properties of cannabidiol is not a prominent feature; in three seizure models, tolerance developed in one, but “reverse tolerance” developed in the other two; and (5) the results of a study of the electrophysiologic mechanisms of action indicate that cannabidiol produces some unique effects and that its spectrum of antiepileptic activity may be different from that of the prototype drugs. The anticonvulsant nature of cannabidiol suggests that it has a therapeutic potential in at least three of the four major types of epilepsy: grand mal, cortical focal, and complex partial seizures.