Association between oxytocin and receptor genetic polymorphisms and aggression in a northern Chinese Han population with alcohol dependence
Association between oxytocin and receptor genetic polymorphisms and aggression in a northern Chinese Han population with alcohol dependence
复制标题
中国北方汉族酒精依赖人群催产素与受体基因多态性与攻击行为的关系
DOI：
10.1016/j.neulet.2016.10.066
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发表时间：
2017
影响因子：
2.5
通讯作者：
Liu Yanlong
中科院分区：
文献类型：
--
作者：
Yang Ling;Wang Fan;Wang Meiling;Han Mei;Hu Lufeng;Zheng Minghua;Ma Ji;Kang Yimin;Wang Pengxiang;Sun Hongqiang;Zuo Wei;Xie Longteng;Wang Aiju;Yu Dongsheng;Liu Yanlong
酒精依赖（Alcohol dependence，AD）是一种常见的慢性脑功能障碍，由生物学、遗传学和环境风险因素之间的复杂相互作用引起。攻击性常常发生在AD的背景下。先前的研究表明，催产素（OXT）和OXT受体（OXTR）参与攻击性的调节。本研究探讨了OXT和OXTR基因的变异和相互作用是否与AD相关的侵略在一个遗传同质的北方中国汉族population.MethodsThree一百二十四男性AD患者和510名男性健康对照（HC）被招募。采用中文版Buss-Perry攻击性问卷作为攻击行为的主观测量工具。使用TaqMan和连接酶检测反应对所有受试者的三种变异rs 2254298、rs 53576和rs6133010进行基因分型。结果rs6133010等位基因频率和基因型频率在AD患者和HC之间差异有统计学意义（p<0.001）。在HCs中，rs 53576 GG基因型对敌对攻击的影响显著强于AA和AG基因型（p= 0.001和p = 0.004），具有rs6133010 AA × rs 2254298 GG × rs 53576 AG互作组合的被试对身体攻击行为有显著影响结论北方汉族人群中，OXT基因rs6133010与AD的发病相关。OXT/R基因多态性可能在AD相关攻击易感性中起重要作用。
ObjectiveAlcohol dependence (AD) is a common chronic brain disorder precipitated by complex interactions between biological, genetic, and environmental risk factors. Aggression often occurs in the context of AD. Previous studies have shown that Oxytocin (OXT) and OXT receptor (OXTR) are involved in the regulation of aggression. The present study investigated whether variations and interactions of OXT and OXTR genes were associated with AD-related aggression in a genetically homogeneous northern Chinese Han population.MethodsThree hundred and twenty-four male AD patients and 510 male healthy controls (HCs) were recruited. A Chinese version of the Buss-Perry Aggression Questionnaire was used as a subjective measurement of aggressive behavior. Three variations, rs2254298, rs53576, and rs6133010 were genotyped using TaqMan and ligase detection reaction for all subjects. Generalized Multifactor Dimensionality Reduction was used to detect interactions between genetic attributes and environmental attributes.ResultsThe frequencies of alleles and genotypes of rs6133010 were significantly different between AD patients and HCs (p<0.001). In HCs, the effect of genotype GG of rs53576 on hostility aggression was significantly stronger than that of genotype AA and AG (p= 0.001 andp= 0.004, respectively), and the subjects with the interaction combination of rs6133010AA × rs2254298GG × rs53576AG exhibited significant effect on physical aggression (p= 0.0107).ConclusionThe present study found that rs6133010 in the OXT gene is associated with AD in the northern Chinese Han population. The polymorphisms of OXT/R may play a key role in the susceptibility of AD-related aggression.