Plasma pyridoxal 5′-phosphate and high-sensitivity C-reactive protein are independently associated with an increased risk of coronary artery disease
Plasma pyridoxal 5′-phosphate and high-sensitivity C-reactive protein are independently associated with an increased risk of coronary artery disease
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DOI：
10.1016/j.nut.2007.12.003
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发表时间：
2008-03-01
期刊：
影响因子：
4.4
通讯作者：
Huang, Yi-Chia
中科院分区：
文献类型：
--
作者：
Cheng, Chien-Hsiung;Lin, Ping-Ting;Huang, Yi-Chia
目的：维生素B6是否与炎症联合对冠状动脉疾病（CAD）的风险发挥独立或协同作用尚不清楚。本研究的目的是调查血浆吡哆醛5 '-磷酸（PLP）是否依赖于或独立于炎症标志物C-反应蛋白（CRP）与CAD的风险。经心导管检查确定为一条主要冠状动脉至少狭窄70%的患者被分配到病例组（n = 184）。对照组（n = 516）由具有正常血液生化值的健康个体组成。结果：血浆PLP浓度与hs-CRP水平仅在对照组呈负相关（-0.001，P = 0.03），而在冠心病组和合并组均无相关性。低血浆PLP（比值比[OR] 2.39）和高hs-CRP（OR 3.37）的CAD风险程度非常相似。低血浆PLP浓度联合低hs-CRP水平（OR 2.34）和高血浆PLP浓度联合高hs-CRP水平（OR 3.61）与CAD风险独立相关。结论：血浆PLP和hs-CRP水平与冠心病的危险性增加独立相关，低PLP和高hs-CRP水平的同时存在增加了冠心病的危险性，其程度几乎是原来的2倍。(C)2008年爱思唯尔公司All rights reserved.
Objective: Whether vitamin B6 exerts an independent or a synergic effect in combination with inflammation for the risk of coronary artery disease (CAD) is unclear. The purpose of this study was to investigate whether plasma pyridoxal 5'-phosphate (PLP) is dependent on or independent of the inflammation marker C-reactive protein (CRP) to associate with the risk of CAD.Methods: This was a hospital-based case-control. Patients were identified with cardiac catheterization as having at least 70% stenosis of one major coronary artery were assigned to the case group (n = 184). The control group(n = 516) was comprised of healthy individuals with normal blood biochemical values. All subjects' height, weight, blood pressure, plasma PLP, homocysteine, high-sensitivity CRP (hs-CRP), and lipid profiles were measured.Results: Plasma PLP concentration was only negatively associated with hs-CRP level in the control group -0.001, P = 0.03) but not in the CAD or pooled groups. The magnitude of the risk of CAD for low plasma PLP (odds ratio [OR] 2.39) and high hs-CRP (OR 3.37) was very similar. Low plasma PLP concentration combined with low hs-CRP level (OR 2.34) and high plasma PLP concentration combined with high hs CRP level (OR 3.61) were independently associated with risk for CAD. However, the combined presence of low PLP and higher hs-CRP levels enhanced the risk of CAD and the magnitude was substantially greater (OR 4.35).Conclusion: Plasma PLP and hs-CRP are independently associated with an increased risk of CAD, the combined presence of low PLP and high hs-CRP enhanced the risk of CAD, and the magnitude was almost double. (C) 2008 Elsevier Inc. All rights reserved.