Preparation of double-raschel knitted silk vascular grafts and evaluation of short-term function in a rat abdominal aorta
Preparation of double-raschel knitted silk vascular grafts and evaluation of short-term function in a rat abdominal aorta
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DOI：
10.1007/s10047-011-0554-z
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发表时间：
2011-02
影响因子：
1.3
通讯作者：
Takahito Yagi;Michiko Sato;Y. Nakazawa;Kimie Tanaka;M. Sata;K. Itoh;Yoshihide Takagi;T. Asakura
中科院分区：
文献类型：
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作者：
Takahito Yagi;Michiko Sato;Y. Nakazawa;Kimie Tanaka;M. Sata;K. Itoh;Yoshihide Takagi;T. Asakura
丝素蛋白纤维因其高强度和韧性而用于缝合线具有悠久的历史。在本文报道的工作中，通过用含有聚乙二醇二缩水甘油醚作为交联剂的丝素蛋白水溶液涂覆双拉舍尔针织丝纤维移植物，制备了直径1.5毫米、长度10毫米的小直径血管移植物。丝素蛋白接枝物最重要的特征是重塑，这是聚酯纤维或膨体聚四氟乙烯接枝物从未观察到的。带涂层的双拉舍尔针织丝纤维移植物具有足够的物理强度，在植入过程中从末端保护梯子。该涂层还可以防止血液从移植物中渗漏，并赋予移植物弹性。将移植物植入大鼠腹主动脉八周后，避免了血栓的早期形成。
Silk fibroin fiber has a long history of use in sutures because of its high strength and toughness. In the work reported in this paper, small-diameter vascular grafts 1.5 mm in diameter and 10 mm in length were prepared by coating a double-raschel knitted silk fiber graft with silk fibroin aqueous solution containing poly(ethylene glycol diglycidyl ether) as a cross-linking agent. The most important character of silk fibroin graft is remodeling, which is never observed for polyester fiber or expanded polytetrafluoroethylene grafts. The double-raschel knitted silk fiber graft with coating has sufficient physical strength and protects the ladder from the end in the implantation process. The coating also gives protection against leakage of blood from the graft, and elasticity to the graft. Eight weeks after implantation of the grafts in rat abdominal aorta, early formation of thrombosis was avoided.