Alterations of dendritic cells in sepsis: featured role in immunoparalysis.
Alterations of dendritic cells in sepsis: featured role in immunoparalysis.
复制标题
DOI：
10.1155/2015/903720
复制
发表时间：
2015
影响因子：
--
通讯作者：
Liang HP
中科院分区：
文献类型：
--
作者：
Fan X;Liu Z;Jin H;Yan J;Liang HP
脓毒症是重症监护病房死亡的主要原因，其特征是早期的炎症反应过度，随后是一段时间的免疫抑制。这种免疫紊乱被认为是与脓毒症的高死亡率密切相关的有效因素。树突状细胞（Dendritic cells，DCs）是专职的抗原提呈细胞，通过激活T淋巴细胞在免疫应答中发挥重要作用。在脓毒症的发展过程中，DC参与了异常的免疫反应，是生存所必需的。因此，更好地了解DCs的病理学无疑将有助于解决脓毒症中出现的问题。本文就脓毒症对DCs数量和功能的影响，包括表面分子表达、细胞因子分泌和T细胞活化等进行综述，并探讨其可能的机制和治疗策略。
Sepsis, the leading cause of mortality in intensive care unit, is characterized by hyperinflammatory response in the early stage and followed by a period of immunosuppression. This immune disorder is believed to be the potent factor that is tightly associated with high mortality in sepsis. Dendritic cells (DCs) serve as professional antigen-presenting cells that play a vital role in immune response by activating T lymphocytes. During the progression of sepsis, DCs have been reported to take part in the aberrant immune response and be necessary for survival. Therefore, a better understanding of the DCs pathology will be undoubtedly beneficial for resolving the problems occurring in sepsis. This review discusses effects of sepsis on DCs number and function, including surface molecules expression, cytokines secretion, and T cell activation, and the underlying mechanism as well as some potential therapeutic strategies.
登录
查看更多内容
影响因子：
4.4
作者：
Bergenfelz, Caroline;Medrek, Catharina;Leandersson, Karin
通讯作者：
Leandersson, Karin
影响因子：
4.4
作者：
Angeli, W;Hammad, H;Trottein, F
通讯作者：
Trottein, F
影响因子：
4.6
作者：
Faivre, V.;Lukaszewicz, A. -C.;Haziot, A.
通讯作者：
Haziot, A.
影响因子：
4.4
作者：
Efron, PA;Martins, A;Moldawer, LL
通讯作者：
Moldawer, LL
影响因子：
3.8
作者：
Chung, CS;Yang, S;Ayala, A
通讯作者：
Ayala, A