Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases-猫眼课题宝

DOI：

10.1038/jhg.2013.129

发表时间：

2013-12

期刊：

Journal of Human Genetics

影响因子：

3.5

通讯作者：

中科院分区：

生物学3区

文献类型：

作者：

Kosuke Tanaka;C. Terao;K. Ohmura;Meiko Takahashi;R. Nakashima;Y. Imura;H. Yoshifuji;N. Yukawa;T. Usui;T. Fujii;T. Mimori;F. Matsuda

虽然CYP3A5多态性与实体器官移植患者他克莫司（TAC）血药浓度之间的相关性已经确定，但在通常接受少量TAC的结缔组织病（CTD）患者中是否也存在这种相关性尚不确定。在这里，我们进行了定量线性回归分析，以解决CTD患者中CYP3A5和血液TAC浓度之间的关联。本研究共招募了72例CTD患者，并对CYP3A5中的rs776746进行了基因分型，这与实体器官移植患者中的TAC浓度密切相关。回顾性获得每例患者每天服用3 mg TAC后的血谷浓度。结果表明，rs776746的等位基因A与TAC血药浓度降低显著相关（P= 0.0038）。携带至少一个A等位基因拷贝的受试者与GG基因型受试者相比，TAC平均浓度降低31.0%。Rs776746与CTD患者的TAC浓度相关。

Although the association between CYP3A5 polymorphism and blood concentration of tacrolimus (TAC) in patients with solid organ transplantation was established, whether the association is also true in patients with connective tissue disease (CTD) who usually receive small amount of TAC is uncertain. Here, we performed a quantitative linear regression analysis to address the association between CYP3A5 and blood TAC concentration in patients with CTD. A total of 72 patients with CTD were recruited in the current study and genotyped for rs776746 in CYP3A5, which showed strong association with TAC concentration in patients with solid organ transplantation. The blood trough concentration of TAC after taking 3 mg per day was retrospectively obtained for each patient. As a result, allele A of rs776746 showed a significant association with a decreasing blood concentration of TAC (P= 0.0038). Those who are carrying at least one copy of the A allele displayed decreased mean concentration of TAC by 31.0% compared with subjects with GG genotype. Rs776746 is associated with concentrations of TAC in patients with CTD.

Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases

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