BRONCHIAL HYPERREACTIVITY AND COUGH DUE TO ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS
BRONCHIAL HYPERREACTIVITY AND COUGH DUE TO ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS
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DOI：
10.1378/chest.95.3.544
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发表时间：
1989-03-01
期刊：
影响因子：
9.6
通讯作者：
SCHLUETER, DP
中科院分区：
文献类型：
--
作者：
KAUFMAN, J;CASANOVA, JE;SCHLUETER, DP
对17名使用血管紧张素转换酶（ACE）抑制剂治疗高血压的患者进行了基线肺量测定，然后通过乙酰甲胆碱激发测定支气管反应性。研究中有9名咳嗽者和8名不咳嗽者。在9名咳嗽者中，8名表现出支气管高反应性。相反，无咳嗽者显示支气管高反应性。9例咳嗽者中有8例在停止ACE抑制剂治疗后2 - 6个月再次激发。这8例中有6例表现出持续的支气管高反应性。我们的结论是咳嗽与潜在的支气管高反应性患者使用ACE抑制剂有关。研究结果提示哮喘患者和已知支气管高反应性患者应谨慎使用ACE抑制剂。
Seventeen patients using angiotensin-coverting enzyme (ACE) inhibitors for hypertension were evaluated with baseline spirometry followed by determination of bronchial reactivity by challenge with methacholine. There were nine coughers and eight noncoughers in the study. Among the nine coughers, eight demonstrated bronchial hyperreactivity. Conversely, none of the noncoughers disclosed bronchial hyperreactivity. Eight of the nine coughers were rechallenged two to six months following cessation of ACE inhibitor therapy. Six of these eight showed persistent bronchial hyperreactivity. We conclude that cough is associated with the use of ACE inhibitors in patients with underlying bronchial hyperreactivity. The findings indicate caution in administration of ACE inhibitors in asthmatic patients and those with known bronchial hyperreactivity.