The dynamic changes of Th17/Treg cytokines in rat liver transplant rejection and tolerance
The dynamic changes of Th17/Treg cytokines in rat liver transplant rejection and tolerance
复制标题
Th17/Treg细胞因子在大鼠肝移植排斥和耐受中的动态变化
DOI：
10.1016/j.intimp.2011.02.010
复制
发表时间：
2011-08-01
影响因子：
5.6
通讯作者：
Gong, Jianping
中科院分区：
文献类型：
--
作者：
Li, Jinzheng;Lai, Xing;Gong, Jianping
急性排斥反应仍然是早期移植物丢失的主要原因，也是移植后受体长期存活的危险因素。最近，CD 4（+）CD 25（+）Foxp 3（+）调节性T（Treg）细胞和Th 17细胞被描述为对自身免疫和移植免疫具有相反作用的两种不同亚群。我们研究了大鼠肝移植耐受组和排斥组之间是否存在Th 17/Treg功能失衡。比较两组患者Th 17/Treg在不同水平上的功能，包括相关的细胞因子分泌和关键的转录因子。与移植后第3天匹配的TOL组相比，REJ组显示Th 17相关细胞因子（IL-17、IL-6和IL-23）和转录因子（ROR γ t）水平显著增加，Treg相关细胞因子（IL-10和TGF-β 1）和转录因子（Foxp 3）水平显著降低。结果表明，大鼠肝移植耐受组和排斥组Th 17/Treg功能失衡，提示Th 17/Treg失衡在急性移植排斥反应的发病机制中可能发挥作用。(C)2011 Elsevier B. V.保留所有权利。
Acute rejection is still a major cause of early graft loss and a risk factor for long-term recipient post-transplant survival. Recently, CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets with opposing effects on autoimmunity and transplant immunity. We investigated the existence of Th17/Treg functional imbalance between tolerance and rejection groups during rat liver transplantation. Then, Th17/Treg functions on different levels were investigated comparatively between those two groups, including related cytokine secretion and key transcription factors. REJ groups revealed significant increase in Th17-related cytokine (IL-17, IL-6 and IL-23) and transcription factor (ROR gamma t) levels and remarkable decrease in Treg-related cytokine (IL-10 and TGF-beta 1) and transcription factor (Foxp3) levels when compared to day-matched TOL groups from day 3 post-transplantation. Results indicated Th17/Treg functional imbalance between tolerance and rejection groups during rat liver transplantation, suggesting a potential role of Th17/Treg imbalance in pathogenesis of acute transplant rejection. (C) 2011 Elsevier B.V. All rights reserved.