CHLORAMPHENICOL (CHLOROMYCETIN) .5. SYNTHESIS
CHLORAMPHENICOL (CHLOROMYCETIN) .5. SYNTHESIS
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DOI：
10.1021/ja01175a066
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发表时间：
1949-01-01
影响因子：
15
通讯作者：
CROOKS, HM
中科院分区：
文献类型：
--
作者：
CONTROULIS, J;REBSTOCK, MC;CROOKS, HM
H I结构的最后证明依赖于合成。在本文中，我们希望报告这种结构的合成和鉴定的异构体形式之一，与抗生素的发酵过程中产生的。Cherbuliez、Neumeier和Lozeron 2报道了通过2-碘-1-苯基-1，3-丙二醇（II）、其乙酸酯或苯甲酸酯与甲胺反应制备与麻黄碱有关的化合物（在侧链的末端碳上带有羟基）和这种结构的衍生物。他们说反应确实
H I the final proofof structure resting upon synthesis. In this paper we wish to report the synthesis of this structure and the identification of one of the isomeric forms with the antibiotic as pro-duced by fermentation procedures. Cherbuliez, Neumeier and Lozeron2 have re-ported the preparation of compounds related to ephedrine, bearing a hydroxyl group on the terminal carbon of the side-chain and derivatives of this structure by reaction of 2-iodo-1-phenyl-1,-3-propandiol, II, its acetate or benzoate, with methylamine. They state that the reaction does