Excessive fluid intake as a cause of chronic diarrhea in young children.
Excessive fluid intake as a cause of chronic diarrhea in young children.
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过量液体摄入是幼儿慢性腹泻的一个原因。
DOI：
10.1016/s0022-3476(83)80008-0
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Ghishan,FK
中科院分区：
文献类型：
--
作者：
Greene,HL;Ghishan,FK
慢性非特异性腹泻发病率的增加与口服液体电解质治疗腹泻的普及是一致的，并导致假设液体摄入量的增加可能与这种发病率的增加有关。在105例转诊患者中，85例没有发现临床或实验室证据表明吸收不良。这些患者中有40例具有CNSD的特征：腹泻至少三周，生长正常，没有肠道病原体的证据。一项门诊研究评估了粪便排出量、膳食能量蛋白摄入量和非蛋白液体摄入量。患者被分为两组，液体摄入量差异较大：A组为196±32 ml/kg/d， B组为91±15 ml/kg/d （P<0.001）。在不改变饮食的情况下，非蛋白液体摄入量减少到90 ml/kg/天。2周和6 - 8周的评估显示，a组所有患者的大便频率（从每天4 - 10次降至每天0 - 3次）都有所减少，大便一致性有所增加，但b组患者的大便模式没有明显变化。我们的研究结果表明，过量液体摄入与某些CNSD病例之间存在因果关系。
An increased incidence of chronic nonspecific diarrhea has been coincident with popularization oforally administered fluid-electrolyte therapy for management of diarrhea, and led up to postulate than an increase in fluid intake might be related to this increased incidence. Of 105 referred patients, 85 were found to have no clinical or laboratory evidence of malabsorption. Forty of these patients had characteristic features of CNSD: diarrhea for at least three weeks, normal growth, and no evidence of enteric pathogens. An outpatient study evaluated fecal output, dietary energy-protein intake, and nonprotein fluid intake. Patients were separated into two groups whose fluid intakes were highly different: group A, 196±32 ml/kg/day, and group B, 91±15 ml/kg/day (P<0.001). The nonprotein fluid intake was then reduced to 90 ml/kg/day with no change in diet. Evaluation at two weeks and again at six to eight weeks showed a decrease in stool frequency (from four to ten per day to zero to three per day) and increase in stool consistency in all patients in group A, but no significant change in stool patterns in group B. Our findings suggest a cause-and-effect relationship between excessive fluid intake and some cases of CNSD.