P25 Resting-state functional connectivity of the human superior colliculus
P25 Resting-state functional connectivity of the human superior colliculus
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P25 人类上丘的静息态功能连接
DOI：
10.1016/j.clinph.2019.04.679
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发表时间：
2019
影响因子：
4.7
通讯作者：
Marc Himmelbach
中科院分区：
文献类型：
--
作者：
Amin Dadashi;Marc Himmelbach
方法我们计算了SC ROI的平均BOLD时间序列。对于每个受试者，计算种子ROI的平均时间序列与每个皮质和皮质下灰度之间的二元零阶（Pearson）相关性。我们使用Fishers变换转换相关系数。我们计算了Z评分图与受试者平均SC-CSF相关性的双尾配对样本t检验，以增加我们分析的特异性。我们使用Z分数符号的随机排列来估计最大t统计量的零分布，以控制家族错误率。零假设拒绝阈值被设置为0.05后，10.000随机permutations.ResultsThe SC连接地图显示枕叶和顶叶皮质区，包括V1至V4，纹外皮质，下顶叶皮质，顶内区和PF复杂。我们还发现了与初级手运动皮层和连接到额叶，运动前区和扣带回的视野，以及与额叶下部和上级颞沟的显着相关性。SC的时间进程也与后丘脑，包括前和内侧枕;同样，有连接到中央外侧，中央正中和小细胞mediodorsal核。在小脑，我们发现广泛的显着相关性的部分小叶VIIB，VIIIA，VIIIB和VI小叶。个体左右侧SC的结果显示，两个半球与各自SC之间的连接基本相同，没有明显的统计学显著差异。观察还表明，腹侧SC的连接布局是背侧SC连接地图的一个子集，而没有独立的皮质功能相关性可以发现在ventralzone.DiscussionThe SC连接地图广泛同意从动物研究的结果。然而，我们还发现了与前额叶，后颞叶和运动前区和初级运动皮层的显着相关性，证实了最近的观察，SC的功能远远超出了视觉，注意力和眼控制。
MethodsWe calculated average BOLD timeseries for SC ROIs. For every subject, bivariate zero-order (Pearson) correlation was calculated between the seed ROIs’ average timeseries and each cortical and subcortical grayordinate. We converted the correlation coefficients, using Fishers” transform. We calculated two-tailed paired-sample t-tests for the Z-score maps against subjects” average SC-CSF correlations to increase the specificity of our analysis. We used random permutations of the Z-score signs to estimate a null distribution of maximum t-statistics to control for the family-wise error rate. The null hypothesis rejection threshold was set to 0.05 after 10.000 random permutations.ResultsThe SC connectivity map revealed occipital and parietal cortex areas including V1 to V4, extrastriate cortex, inferior parietal cortex, intraparietal areas and PF complex. We also found significant correlations with primary hand motor cortex and connections to frontal, premotor and cingulate eye-fields as well as significant correlations with inferior frontal areas and superior temporal sulcus. SC timecourses also correlated with the posterior thalamus, including anterior and medial pulvinar; likewise, there are connections to central lateral, centre median and parvocellular mediodorsal nuclei. In the cerebellum, we found extensive significant correlations with parts of the lobules VIIB, VIIIA, VIIIB and VI lobules. The results of the individual left and right SCs showed largely identical connections between the either hemisphere and the respective SC with no noticeable statistically significant difference. Observations also show that the connectivity layout of the ventral SC is a subset of dorsal SC connectivity map, while no independent cortical functional correlation could be found at the ventral zone.DiscussionThe SC connectivity map widely agrees with the findings from animal studies. However, we also found significant correlations with prefrontal, posterior temporal and premotor and primary motor cortex that confirmed recent observations that functions of the SC reach far beyond vision, attention, and oculomotor control.