Density and maturity of peritumoral tertiary lymphoid structures in oesophageal squamous cell carcinoma predicts patient survival and response to immune checkpoint inhibitors.
Density and maturity of peritumoral tertiary lymphoid structures in oesophageal squamous cell carcinoma predicts patient survival and response to immune checkpoint inhibitors.
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DOI：
10.1038/s41416-023-02235-9
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发表时间：
2023-06
影响因子：
8.8
通讯作者：
Doki, Yuichiro
中科院分区：
文献类型：
--
作者：
Hayashi, Yoshinori;Makino, Tomoki;Sato, Eiichi;Ohshima, Kenji;Nogi, Yuya;Kanemura, Takashi;Honma, Keiichiro;Yamashita, Kotaro;Saito, Takuro;Tanaka, Koji;Yamamoto, Kazuyoshi;Takahashi, Tsuyoshi;Kurokawa, Yukinori;Miyata, Hiroshi;Nakajima, Kiyokazu;Wada, Hisashi;Morii, Eiichi;Eguchi, Hidetoshi;Doki, Yuichiro
三级淋巴样结构（TLS）是非淋巴样组织中的异位淋巴样聚集体，其与某些癌症类型的预后改善相关。本研究旨在探讨TLSs在食管癌中的临床意义。在一系列的316 EC手术标本从两个不同的研究所，我们评估了密度和成熟的瘤周TLS使用苏木精/伊红，免疫组化和多重免疫荧光染色。我们分析了TLS和临床病理参数之间的关联。在34名接受抗PD-1抗体治疗的复发性EC患者的不同队列中进一步评估了TLR的临床意义。具有高TLS密度的肿瘤主要由成熟的TLS组成。高TLS密度与肿瘤分期较低、无淋巴/血管浸润、血清营养参数（中性粒细胞计数、白蛋白、嗜中性粒细胞与淋巴细胞比率和预后营养指数）较好以及生存期延长显著相关。这种存活趋势在具有成熟TLS的病例中更为显著，这代表了CD 138+浆细胞群体的增加。在第二个EC队列中，TLS密度预测了抗PD-1抗体的临床应答和患者生存期。肿瘤周围TLS的密度和成熟度是预测EC患者长期生存和对抗PD-1抗体治疗反应的有用参数。
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates in non-lymphoid tissues, which are associated with improved prognosis in some cancer types. This study aimed to investigate the clinical significance of TLSs in oesophageal cancer (EC). In a series of 316 EC surgical specimens from two different institutes, we evaluated the density and maturity of peritumoral TLSs using haematoxylin/eosin, immunohistochemistry, and multiplex immunofluorescence staining. We analysed the association between TLSs and clinicopathological parameters. The clinical significance of TLSs was further evaluated in a different cohort of 34 patients with recurrent EC treated with anti-PD-1 antibody. Tumours with high TLS density predominantly consisted of matured TLSs. High TLS density was significantly associated with less advanced tumour stage, absence of lymphatic/vascular invasion, better serum nutrition parameters (neutrophils count, albumin, neutrophil-to-lymphocyte ratio, and prognostic nutritional index), and prolonged survival. This survival trend was more remarkable in cases with matured TLSs, which represented an increased population of CD138+ plasma cells. In the second EC cohort, TLS density predicted the clinical response to anti-PD-1 antibody and patient survival. The density and maturity of peritumoral TLSs are useful parameters for predicting long-term survival and response to anti-PD-1 antibody treatment in EC patients.
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影响因子：
64.8
作者：
Helmink BA;Reddy SM;Gao J;Zhang S;Basar R;Thakur R;Yizhak K;Sade-Feldman M;Blando J;Han G;Gopalakrishnan V;Xi Y;Zhao H;Amaria RN;Tawbi HA;Cogdill AP;Liu W;LeBleu VS;Kugeratski FG;Patel S;Davies MA;Hwu P;Lee JE;Gershenwald JE;Lucci A;Arora R;Woodman S;Keung EZ;Gaudreau PO;Reuben A;Spencer CN;Burton EM;Haydu LE;Lazar AJ;Zapassodi R;Hudgens CW;Ledesma DA;Ong S;Bailey M;Warren S;Rao D;Krijgsman O;Rozeman EA;Peeper D;Blank CU;Schumacher TN;Butterfield LH;Zelazowska MA;McBride KM;Kalluri R;Allison J;Petitprez F;Fridman WH;Sautès-Fridman C;Hacohen N;Rezvani K;Sharma P;Tetzlaff MT;Wang L;Wargo JA
通讯作者：
Wargo JA
影响因子：
9
作者：
通讯作者：
--
影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
影响因子：
30.5
作者：
Finkin S;Yuan D;Stein I;Taniguchi K;Weber A;Unger K;Browning JL;Goossens N;Nakagawa S;Gunasekaran G;Schwartz ME;Kobayashi M;Kumada H;Berger M;Pappo O;Rajewsky K;Hoshida Y;Karin M;Heikenwalder M;Ben-Neriah Y;Pikarsky E
通讯作者：
Pikarsky E
影响因子：
64.8
作者：
Cabrita, Rita;Lauss, Martin;Jonsson, Goran
通讯作者：
Jonsson, Goran