MORPHOLOGY AND MECHANICAL PROPERTIES OF THE SUBRENAL AORTA IN NORMOTENSIVE AND HYPERTENSIVE RATS
MORPHOLOGY AND MECHANICAL PROPERTIES OF THE SUBRENAL AORTA IN NORMOTENSIVE AND HYPERTENSIVE RATS
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DOI：
10.5507/bp.2008.037
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发表时间：
2008-12-01
影响因子：
0.9
通讯作者：
Kuncova, Jitka
中科院分区：
文献类型：
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作者：
Kochova, Petra;Tonar, Zbynek;Kuncova, Jitka
目的：本工作重点研究肾次全切除术（NX）诱发动脉高血压和慢性肾功能衰竭的大鼠肾下主动脉壁的形态和力学变化。方法：采用体视学方法评估定量结构参数。采用单轴拉伸试验测定机械性能。结果：形态学结果显示，肾次全切除术后十天的NX大鼠的壁结构与对照动物相比没有显着差异。肾切除术后十周出现明显的结构变化。专业人士的面积。 NX 大鼠的动脉管腔体积、弹性蛋白体积分数以及中膜中弹性蛋白层数均显着高于对照动物。 NX 动物的中膜中平滑肌细胞的体积分数和层状单位厚度的值显着较低。力学结果表明，两种组织在进行拉伸测试时均表现出非线性响应。对照动物和 NX 动物肾下主动脉的弹性模量仅在大变形时不同：NX 样品具有更高的刚度。循环负荷导致两种组织类型出现时间依赖性反应。结论：NX 大鼠术后十天和十周获得的结果表明主动脉向外肥厚。与对照动物相比，NX 动物的肾下主动脉强度较小，伸展性较差。
Aims: This work focuses on the morphological and mechanical changes in the wall of the subrenal aorta in rats suffering from arterial hypertension and chronic renal failure induced by subtotal nephrectomy (NX).Methods: The quantitative structural parameters were assessed using stereological methods. The mechanical properties were determined using uniaxial tensile tests.Results: Morphological results showed no significant differences in the wall structure of NX rats ten days following the subtotal nephrectomy in comparison with the control animals. Pronounced structural changes appeared ten weeks after the nephrectomy. The area of the pro. le of the arterial lumen, the volume fraction of elastin, and the elastin lamellar number in the tunica media were significantly higher in the NX rats than in the control animals. The values of the volume fraction of the smooth muscle cells in the tunica media and the lamellar unit thickness were significantly lower for the NX animals. Mechanical results showed that both kinds of tissues were characterized by a non-linear response when subjected to the tensile test. The moduli of elasticity of subrenal aortas in control and NX animals were different only for large deformations: NX samples had higher stiffness. The cyclic loading resulted in a time-dependent response for both tissue types.Conclusions: The results obtained from the NX rats ten days as well as ten weeks after operation suggested an outward hypertrophy of the aorta. The subrenal aortas of the NX animals had less strength and were less extensible than those of the control animals.