Glycated albumin is lower in Infants than in adults and correlated with both age and serum albumin
Glycated albumin is lower in Infants than in adults and correlated with both age and serum albumin
复制标题
婴儿的糖化白蛋白低于成人，且与年龄和血清白蛋白相关
DOI：
10.1111/j.1399-5448.2012.00895.x
复制
发表时间：
2012
期刊：
影响因子：
3.4
通讯作者：
Shigeru Suzuki
中科院分区：
文献类型：
--
作者：
Takuya Furuhashi;Chiyo Saito;Kan Torii;Emi Nishida;Akimichi Morita;古橋卓也，齋藤稚代，鳥居寛，西田絵美，森田明理;古橋卓也，齋藤稚代，鳥居寛，西田絵美，森田明理;古橋卓也;古橋卓也;Shigeru Suzuki;Shigeru Suzuki
糖化白蛋白(GA)反映新生儿糖尿病(NDM)患者的血糖控制情况。目的建立正常新生儿GA的参考区间。方法对58例健康足月新生儿的GA参考值进行测定，并探讨其与血糖、血清白蛋白的关系。按年龄分为三组：A组5(4-6)d：N = 18，B组33(30-38)d：N = 19，C组181(50-352)d：N = 21。结果在婴儿中，GA与年龄的对数转化呈显著正相关(p=0.831，p<；0.0001)。A、B、C、D组GA分别为7.3 ± 1.0%、8.6 ± 1.1%、10.9 ± 0.8%、14.0 ± 1.1%。GA与血清白蛋白呈正相关(r = 0.768，p<；0.0001)，与PG(r = 0.596，p<；0.0001)呈显著正相关。当GA水平与年龄相关的参考值进行比较时，尽管4例永久性NDM患者的GA有所下降，但在胰岛素治疗后仍保持在较高水平，但一过性NDM患者的GA正常。结论本研究显示婴幼儿GA的参考值范围低于成人，并随着年龄的增长而增加，证实了NDM患者的GA反映了临床病程。因此，应该将NDM患者的GA与基于年龄的参考值进行比较，以评估准确的血糖状况。
BackgroundGlycated albumin (GA) reflects glycemic control in patients with neonatal diabetes mellitus (NDM). However, GA in NDM patients is apparently low in relation to glycemia.ObjectiveTo establish the reference intervals for GA in healthy infants.Subjects and MethodsFifty‐eight healthy, full‐term newborn infants were used to define the GA reference values and to investigate its relationship to plasma glucose (PG) and serum albumin. The infants were categorized into three groups according to age: group A, 5 (4–6) median (range) d: n = 18; group B, 33 (30–38) d: n = 19; and group C, 181 (50–352) d: n = 21. We also studied 212 non‐diabetic adults [group D, 53 (28–78) yr old] and the 5 NDM patients previously reported for GA comparisons.ResultsIn the infants, GA was strongly positively correlated with logarithmic transformation of age [log (age)] (p = 0.831, p < 0.0001). The GA in groups A, B, C, and D were 7.3 ± 1.0%, 8.6 ± 1.1%, 10.9 ± 0.8%, and 14.0 ± 1.1%, respectively. The GA was more strongly positively correlated with serum albumin (r = 0.768, p < 0.0001) than with PG (r = 0.596, p < 0.0001). When GA levels were compared with the age‐dependent reference values, GA in the transient NDM patient was normalized although GA in the four permanent NDM patients decreased but remained high after insulin therapy.ConclusionsThis study showed that the reference range for GA in infants is lower than that of adults and increases with age, with which we confirmed that GA in the NDM patients reflected the clinical course. Consequently, GA in NDM patients should be compared with the age‐based reference values to assess the accurate glycemic status.