Dentin Proteins: Chemistry, Structure and Biosynthesis
Dentin Proteins: Chemistry, Structure and Biosynthesis
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牙本质蛋白：化学、结构和生物合成
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
W. Richardson
中科院分区：
文献类型：
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作者：
W. Butler;E. Munksgaard;W. Richardson
牙本质中最丰富的非胶原蛋白之一是富含天冬氨酸和磷酸丝氨酸的磷蛋白。这种蛋白质以可溶性和不可提取的形式存在，后者与不溶性胶原基质相关。这种蛋白质能够紧密结合相对高水平的钙。生物合成和放射自显影数据表明，在其生物合成后不久，磷蛋白被运输并结合到前牙本质-牙本质交界处的胶原蛋白上。这一事件可能是中心的矿化过程，虽然其他糖蛋白可能参与。
One of the most abundant noncollagenous proteins of dentin is a phosphoprotein rich in aspartic acid and phosphoserine. This protein occurs in soluble and inextractable forms, the latter being associated with the insoluble collagenous matrix. This protein is capable of tightly binding a relatively high level of calcium. Biosynthetic and radioautographic data suggest that shortly after its biosynthesis, the phosphoprotein is transported and bound to the collagen at the predentin-dentin junction. This event is probably central to the mineralization process, though other glycoproteins may be involved.