A behavioral and cognitive profile of clinically stable HIV-infected children
A behavioral and cognitive profile of clinically stable HIV-infected children
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DOI：
10.1542/peds.2005-0451
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发表时间：
2006-03-01
期刊：
影响因子：
8
通讯作者：
Pelton, S
中科院分区：
文献类型：
--
作者：
Nozyce, ML;Lee, SS;Pelton, S
OBJECTIVE.本研究的目的是描述临床和免疫学稳定的抗逆转录病毒治疗的HIV感染儿童的行为和认知特征。对274名年龄在2 ~ 17岁的HIV感染儿童进行了行为、发育和认知功能评估。研究神经心理学指标、年龄和CD 4淋巴细胞计数之间的相关性。最常见的行为问题，根据Conners父母评定量表的测量，是心身（28%），学习（25%），多动（20%），冲动多动（19%），行为（16%）和焦虑（8%）问题。平均韦氏儿童智力量表-III评分低于既定的人群标准;平均言语智商为85，平均操作智商为90，平均全量表评分为86。多动在韦氏儿童智力量表III表现智商≥ 9岁的儿童中更常见< 90. Anxiety problems were more likely in children >。CD 4计数< 660个细胞/mm（3）的儿童更有可能被确定为患有行为障碍。行为问题与神经影像学检查之间无相关性。临床和免疫学稳定的HIV感染儿童有更频繁的行为问题和较低的发展和认知得分比既定的儿童规范。
OBJECTIVE. The purpose of this research was to characterize behavioral and cognitive profiles of clinically and immunologically stable antiretroviral-experienced HIV-infected children.METHODS. Two hundred seventy-four previously treated HIV-infected children aged 2 to 17 years were assessed for behavioral, developmental, and cognitive functioning. Correlations between neuropsychological measures, age, and CD4 lymphocyte count were investigated.RESULTS. The most common behavioral problems, as measured by the Conners' Parent Rating Scale, were psychosomatic (28%), learning (25%), hyperactivity (20%), impulsive-hyperactive (19%), conduct (16%), and anxiety (8%) problems. Mean Wechsler Intelligence Scale for Children-III scores were less than established population norms; the mean verbal IQ was 85, the mean performance IQ was 90, and the mean full-scale score was 86. Hyperactivity was more frequent in children with a Wechsler Intelligence Scale for Children-III performance IQ of < 90. Anxiety problems were more likely in children >= 9 years of age. Children with CD4 counts of < 660 cells per mm(3) were more likely to be identified as having a conduct disorder. No association was noted between behavioral problems and neuroimaging.CONCLUSIONS. Clinically and immunologically stable HIV-infected children had more frequent behavioral problems and lower developmental and cognitive scores than established childhood norms.