Smoking cessation improves insulin sensitivity in healthy middle-aged men
Smoking cessation improves insulin sensitivity in healthy middle-aged men
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DOI：
10.1046/j.1365-2362.1997.1330680.x
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发表时间：
1997-05-01
影响因子：
5.5
通讯作者：
Smith, U
中科院分区：
文献类型：
--
作者：
Eliasson, B;Attvall, S;Smith, U
吸烟者最近被证明表现出胰岛素抵抗、血脂异常和胰岛素抵抗综合征（IRS）的标志物。本研究的目的是检查戒烟对胰岛素敏感性和IRS的影响。40名男性非肥胖健康吸烟者参加了这项开放平行研究，随访8周。17名受试者能够戒烟，而23名受试者继续吸烟并作为对照组。测量人体测量和代谢数据。用正常血高胰岛素钳夹技术测定胰岛素敏感性程度。戒烟增加胰岛素敏感性和改善脂蛋白谱，尽管在体重适度增加。最初的吸烟习惯与BMI的增加以及戒烟后代谢变量的改善呈正相关。这些数据支持吸烟导致胰岛素抵抗和IRS的观点，并且还表明戒烟的有益代谢作用超越了伴随的体重适度增加的影响。
Cigarette smokers have recently been shown to exhibit insulin resistance, dyslipidaemia and markers of the insulin resistance syndrome (IRS). The aim of this study was to examine the effects of smoking cessation on insulin sensitivity and IRS. Forty male, non-obese healthy smokers participated in this open parallel study with 8 weeks of follow-up. Seventeen subjects were able to stop smoking, while 23 subjects continued to smoke and served as a controls group. Anthropometric and metabolic data were measured. Degree of insulin sensitivity was determined with the euglycaemic hyperinsulinaemic clamp technique. Smoking cessation increased insulin sensitivity and improved the lipoprotein profile in spite of a modest increase in body weight. Initial smoking habits correlated positively with the increase in BMI as well as the improvements in the metabolic variables after smoking cessation. These data support the view that smoking causes insulin resistance and IRS, and also demonstrate that the beneficial metabolic effects of smoking cessation override the effects of an accompanying modest increase in body weight.