4-Phenyl-3,4-dihydroquinolone Derivatives from Aspergillus nidulans MA-143, an Endophytic Fungus Isolated from the Mangrove Plant Rhizophora stylosa
4-Phenyl-3,4-dihydroquinolone Derivatives from Aspergillus nidulans MA-143, an Endophytic Fungus Isolated from the Mangrove Plant Rhizophora stylosa
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DOI：
10.1021/np4004646
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发表时间：
2013-10-01
影响因子：
5.1
通讯作者：
Wang, Bin-Gui
中科院分区：
文献类型：
--
作者：
An, Chun-Yan;Li, Xiao-Ming;Wang, Bin-Gui
从海生红树根霉（Rhizophora stylosa）鲜叶内生真菌nidulans MA-143中分离鉴定了6个新的4-苯基-3,4-二氢喹诺酮衍生物（1-6）和相关的aflaquinolone A(7)。通过光谱分析和电子圆二色性实验确定了化合物1的绝对构型和结构，通过单晶x射线晶体学分析确定了化合物1的结构。在生物筛选实验中，分离的化合物均未显示出有效的抗菌或细胞毒活性。化合物2、3、7对卤对虾（Artemia sauna）具有较强的致死能力，其LD50值分别为7.1、4.5和5.5 μ M。
Six new 4-phenyl-3,4-dihydroquinolone derivatives (1-6) along with the related aflaquinolone A (7) were isolated and identified from the cultures of Aspergillus nidulans MA-143, an endophytic fungus obtained from the fresh leaves of the marine mangrove plant Rhizophora stylosa. Their structures including absolute configurations were determined by spectroscopic analysis and electronic circular dichroism experiments, and the structure of compound 1 was confirmed by single-crystal X-ray crystallographic analysis. In bioscreening experiments, none of the isolated compounds showed potent antibacterial or cytotoxic activity. However, compounds 2, 3, and 7 exhibited lethality against brine shrimp (Artemia sauna), with LD50 values of 7.1, 4.5, and 5.5 mu M, respectively.