Ornithine Decarboxylase Antizyme Protein and Inhibition of Cell Proliferation
Ornithine Decarboxylase Antizyme Protein and Inhibition of Cell Proliferation
复制标题
DOI：
--
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
M. Wenli
中科院分区：
文献类型：
--
作者：
M. Wenli
所有的功能性抗酶都是通过一种独特的核糖体移码机制翻译的。抗酶与鸟氨酸脱羧酶结合，促进26S蛋白酶体降解ODC。它们负向调节多胺，抑制细胞生长。此外，它们可以通过与细胞周期蛋白D1结合，促进泛素依赖性降解，从而阻止细胞周期。此外，OAZ可以逆转肿瘤细胞的分化。它们在多种肿瘤中弱表达，在肿瘤的基因治疗中发挥着重要作用。
The whole functional antizymes were translated by a unique ribosomal frameshift mechanism. Antizymes bind to ornithine decarboxylase and promote degradation of ODC by 26S proteasome. They negatively regulate polyamines and suppress the growth of cells. Also, they can arrest cell cycle via binding to cyclin D1 and promoting the ubiquitin-dependent degradation. Moreover, OAZ can reverse differentiation of tumour cells. They are weakly expressed in a variety of tumors and play important roles in the gene therapy for tumors.