Effect of (-)-DS 121 and (+)-UH 232 on cocaine self-administration in rats.
Effect of (-)-DS 121 and (+)-UH 232 on cocaine self-administration in rats.
复制标题
(-)-DS 121 和 ( )-UH 232 对大鼠可卡因自我给药的影响。
DOI：
10.1007/bf02246149
复制
发表时间：
1995
影响因子：
3.4
通讯作者：
Roberts,DC
中科院分区：
文献类型：
--
作者：
Smith,A;Piercey,M;Roberts,DC
The novel dopamine autoreceptor antagonists (−)-DS 121 and (+)-UH 232 were tested for their ability to alter cocaine self-administration behavior in rats reinforced on a progressive ratio (PR) schedule. (−)-DS 121 (15 mg/kg) and (+)-UH 232 (30 mg/kg) produced significant decreases in breaking point. (−)-DS 121 produced variable results on rate of cocaine intake on an FR1 schedule, indicating that rate may on occasion be insensitive to changes in cocaine reinforcement. In animals previously trained to self-administer cocaine, (−)-DS 121 failed to maintain responding when substituted for cocaine. This profile suggests that (−)-DS 121 is a promising new candidate for the treatment of cocaine abuse.
