Symmetry-based nonperturbative micromanipulation in a three-dimensional microfluidic device
Symmetry-based nonperturbative micromanipulation in a three-dimensional microfluidic device
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DOI：
10.1103/physrevfluids.5.044202
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发表时间：
2020-04-27
影响因子：
2.7
通讯作者：
Liu, Bin
中科院分区：
文献类型：
--
作者：
Gonzalez, Jeremias;Liu, Bin
我们介绍了一种适合三维（3D）微操作的微流体设计，通过一组具有嵌入式对称性的双层通道实现。对于六通道配置，我们表明器件中心的零应变率受到这些对称性的保护，从而导致在3D中沿任何方向的非扰动操作流。我们通过有限元模拟可视化了这种非微扰流动结构，并证实了这种对称保护的无应变条件。除了这种三维非微扰操作，我们揭示了两种不同的微扰流动模式，在这个六通道装置中可用，对应于与自由度计数一致的五种独立模式。这种基于对称的微操作与传统显微镜完全兼容，可以很容易地扩展到其他通道几何形状，用于丰富的生物和物理应用。
We introduce a microfluidic design that is desirable for three-dimensional (3D) micro-manipulation, achieved through a set of double-layer channels with embedded symmetries. For the six-channel configuration, we show that a zero strain rate at the center of the device is protected by these symmetries, leading to a nonperturbative manipulation flow along any direction in 3D. We visualize such a nonperturbative flow structure through a finite element simulation and confirm this symmetry-protected strain-free condition. In addition to such 3D nonperturbative manipulations, we reveal two distinct perturbative flow modes available in this six-channel device, corresponding to a total of five independent modes that agrees with the degree-of-freedom counting. This symmetry-based micromanipulation is fully compatible with conventional microscopes and can be easily extended to other channel geometries for rich biological and physical applications.