Expression of SMAD signal transduction molecules in the pancreas
Expression of SMAD signal transduction molecules in the pancreas
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DOI：
10.1007/s004180100316
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发表时间：
2001-09-01
影响因子：
2.3
通讯作者：
Larsson, LI
中科院分区：
文献类型：
--
作者：
Brorson, M;Hougaard, DM;Larsson, LI
细胞因子的TGF-β超家族的成员与胰腺癌、胰腺炎以及胰腺内分泌和外分泌细胞的调节和分化有关。不同的TGF-β成员通过不同的信号转导蛋白的磷酸化发出信号，这些信号转导蛋白最终与SMAD 4形成寡聚体并易位到细胞核。逆转录-聚合酶链反应显示SMADs 1、2和4在胰岛中表达。免疫组化显示SMAD 1和SMAD 4主要由胰岛胰岛素和胰高血糖素细胞表达。由于SMAD 1已知可阻断来自结合骨形态发生蛋白（BMP）的受体的信号，这些结果表明BMP样配体在胰岛功能中的先前未知的作用。
Members of the TGF-beta superfamily of cytokines have been implicated in pancreatic cancer, pancreatitis and in regulation and differentiation of pancreatic endocrine and exocrine cells. Different TGF-beta members signal through phosphorylation of different signal transduction proteins, which eventually form oligomers with SMAD 4 and translocate to the nucleus. Reverse transcriptase-polymerase chain reaction showed that SMADs 1, 2 and 4 are expressed in pancreatic islets. Immunostaining revealed that SMAD 1 and 4 predominantly were expressed by islet insulin and glucagon cells. Since SMAD 1 is known to transduce signals from receptors binding bone morphogenetic protein (BMP) these results indicate a previously unknown role of BMP-like ligands in islet function.