Polarity and sex effect in genetic transmission of affective disorders. The single major locus hypothesis.
Polarity and sex effect in genetic transmission of affective disorders. The single major locus hypothesis.
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情感障碍遗传传播中的极性和性别效应。
DOI：
10.1159/000153360
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发表时间：
1983
期刊：
影响因子：
1.8
通讯作者：
M. Baron
中科院分区：
文献类型：
--
作者：
M. Baron
一个单一的主要基因座模型的遗传，包括极性（双极单极的区别）和性别效应，适用于双相和单极情感障碍的家庭研究数据。在测试的模型中，临床极性和性别相关的阈值决定了对重大情感疾病的不同责任，其中单极女性和双极男性代表了遗传环境连续体上的两个极端。双相男性更偏离，和单极女性较少偏离基因比双相女性和单极男性。主基因座假说没有提供一个可接受的数据拟合。这些研究结果的影响，在情感障碍的遗传和生物学研究进行了讨论。
A single major locus model of inheritance that incorporates polarity (bipolar-unipolar distinction) and sex effect was applied to family study data on bipolar and unipolar affective disorders. In the model tested, clinical polarity and sex-related thresholds determined a differential liability to major affective illness, whereby unipolar females and bipolar males represented two extremes on a genetic-environmental continuum. Bipolar males were more deviant, and unipolar females were less deviant genetically than bipolar females and unipolar males. The major locus hypothesis did not provide an acceptable fit to the data. The implications of these findings for genetic and biological research in affective disorders are discussed.