Evaluation of error levels in hemoglobin A1c and glycated albumin in type 2 diabetic patients due to inter-individual variability
Evaluation of error levels in hemoglobin A1c and glycated albumin in type 2 diabetic patients due to inter-individual variability
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DOI：
10.1016/j.diabres.2010.04.007
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发表时间：
2010-08-01
影响因子：
5.1
通讯作者：
Shima, Kenji
中科院分区：
文献类型：
--
作者：
Tahara, Yasuhiro;Shima, Kenji
目的：探讨2型糖尿病患者糖化血红蛋白(A1C)和糖化白蛋白(GA)的个体差异。方法：选择血糖控制稳定且无并发症影响的2型糖尿病患者(n=154，年龄68.4±9.9岁)。每隔2~3个月进行一次早餐或午餐后1~4h的血检，共3次。结果：糖化血红蛋白和糖化血红蛋白与餐后血糖显著相关。当使用原始数据计算时，A1C和GA之间的相关系数为0.728(p<；0.001)，当使用每个患者的平均数据计算时，相关系数为0.747(p<；0.001)。GA与A1C的比值为3.88+/-0.50(原始数据)和3.88+/-0.47(平均数据)，变异系数分别为12.9%和12.1%。多元回归分析使变异系数(R)降至11.2%。将CV(R)(2)划分为CV(A1C)(2)和CV(GA)(2)后，计算出原始数据的CV(A1C)和CV(GA)分别为9.1%和8.6%，经多元回归分析后降至7.9%。结论：A1C和GA的误差水平在7.9-9.1%之间，A1C和GA的误差最大为18%。(C)2010年，爱思唯尔爱尔兰有限公司出版。
Aim: To evaluate error levels in hemoglobin A1c (A1C) and glycated albumin (GA) in type 2 diabetic patients due to inter-individual variability.Methods: Type 2 diabetic patients with stable glycemic control and without complications affecting either A1C or GA were enrolled (n = 154; age 68.4 +/- 9.9 years). Blood examination was performed 1-4 h after breakfast or lunch every 2-3 months on >= 3 occasions. A1C data were changed to IFCC values for analysis.Results: A1C and GA correlated significantly with postprandial plasma glucose. The correlation coefficient between A1C and GA was 0.728 (p < 0.001) when calculated using raw data and 0.747 (p < 0.001) when calculated using averaged data for each patient. The ratio R of GA to A1C was 3.88 +/- 0.50 for raw data and 3.88 +/- 0.47 for averaged data, indicating coefficients of variation of R (CV(R)) of 12.9% and 12.1%, respectively. Multiple regression analysis reduced CV(R) to 11.2%. After dividing CV(R)(2) into CV(A1C)(2) and CV(GA)(2), CV(A1C) and CV(GA) were calculated as 9.1% for raw data and 8.6% for averaged data, and were reduced to 7.9% after multiple regression analysis.Conclusions: Error levels in A1C and GA reach 7.9-9.1%, suggesting the existence of maximal 18% errors in A1C and GA levels. (C) 2010 Published by Elsevier Ireland Ltd.