MALIGNANT NEOPLASMS OF GENETIC ORIGIN IN DROSOPHILA-MELANOGASTER
MALIGNANT NEOPLASMS OF GENETIC ORIGIN IN DROSOPHILA-MELANOGASTER
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DOI：
10.1126/science.96525
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发表时间：
1978-01-01
期刊：
影响因子：
56.9
通讯作者：
GATEFF, E
中科院分区：
文献类型：
--
作者：
GATEFF, E
讨论了12种隐性致死性突变体中发生的恶性肿瘤。这些突变影响成体视神经母细胞和幼虫脑、影像盘和造血器官中的神经节母细胞。恶性肿瘤表现为快速，自主生长，分化能力丧失，移动性和侵袭性增加，原位和移植后的致死率，组织学，精细结构和核型异常。中间肿瘤是良性和恶性兼而有之。它们以无创、致密的方式生长，是典型的良性肿瘤，但在移植到野生型宿主后表现出快速、自主和致死性生长、分化能力丧失、细胞形态改变和致死性生长等恶性特性。果蝇和脊椎动物的肿瘤有惊人的相似之处。
Malignant neoplasms that develop in 12 recessive-lethal, larval mutants of D. melanogaster are discussed. These mutations affect the adult optic neuroblasts and ganglion-mother cells in the larval brain, the imaginal discs, and the hematopoietic organs. The malignant neoplasms exhibit fast, autonomous growth, loss of differentiation capacity increased mobility and invasivness, lethality in situ and after transplantation, and histological, fine structural and karyotypic abnormalities. Intermediate neoplasma are found which combine benign and malignant qualities. They grow in a noninvasive, compact fashion, typical of benign tumors, yet exhibit malignant qualities such as fast, autonomous and lethal growth, loss of differentiation capacity, changes in cellular morphology and lethal growth after transplantation into wild-type hosts. Drosophila and vertebrate neoplasms show striking similarities.